A glowing report from a molecule could make life easier for diabetic
patients by allowing them to continually monitor levels of glucose in
their blood without the need for a pinprick test. The technique being
developed by researchers at Strathclyde University in Glasgow and Guy's
Hospital in London also offers a healthy view of how well physics,
chemistry and biology can work together.
As millions of diabetic people worldwide know, needles are a pain. It is
not just the repeated need to inject insulin which is unpopular, but also
taking pinprick blood samples to monitor blood sugar levels every day,
whether at a visit to the doctor or at home. According to David Birch
of Strathclyde University, "Non-invasive glucose sensing is a priority to
improve the everyday management of patients with diabetes mellitus,
especially for detection of hypoglycaemia (low blood glucose
concentrations)."
Birch and colleague
John Pickup at King's College London-Guy's Hospital and their teams
are working together to design a simple device that might be implanted
under the skin to continuously monitor blood sugar from outside the body.
The device should help patients keep closer tabs on their blood sugar and
so help them prevent dangerous increases in blood glucose that are thought
to lead to the damaging long-term effects of diabetes, such as kidney, eye
and nerve disease, by injecting their insulin precisely when it's needed;
even when they are driving, operating machinery or asleep.
The scientific challenges have been mainly those associated with crossing
disciplines, a recognised frontier for the new millennium. "Physicists
traditionally love relatively simpler systems such as atoms because they
offer the best chance of furthering our fundamental understanding of
matter," Birch told us. "However, life is essentially a molecular
phenomenon and the molecules that matter most in nature are complex and
rarely play by the physicists rulebook as we know it, but they seem to
know what they are doing alright!"
Molecular structure of glucose - C6H12O6
(chemical formula)
The secrets of clouds of atoms, quantum entanglement and antimatter might one
day be revealed with a little help from British physicists.
"Everything has suddenly come together after 18 months of struggling to make
things work," that's what Ed Hinds told us, "Both our atom chip
experiments are suddenly producing fantastic data!" he added. Hinds tale is a
chilling one of experiments that reach the coldest parts of nature with a view
to building new quantum devices using ultracold atoms instead of electrons.
Absolute zero is unimaginably cold. An industrial deep-freeze is balmy in
comparison. How about liquid nitrogen, the classic undergraduate demonstration
material for smashing daffodils and rubber gloves? Even that's at a relatively
scorching 63.25 degrees above absolute zero. Might the darkest depths of space
at an almost clement 3 degrees above absolute zero be adequate?
Hinds thinks not. He and his team work at less than a millionth of a
degree above the coldest of cold. At this temperature, whole atoms act like
waves instead of particles and follow the strange rules of quantum mechanics.
"We start to see quantum effects, such as interference, in the motion of whole
atoms, not just the electrons within them," Hinds explains, "Being able to
manipulate clouds of atoms as quantum objects is already very exciting," says
Hinds. It could also be very practical paving the way for making quantum
circuits with atoms.
Such devices are still some way off. "At the moment, we know very little
about how to use these new quantum effects for useful applications," concedes
Hinds, "but it is clearly very powerful and theorists are working hard on
thinking about this." Ultimately, interference between many quantum logic gates
- on an atom chip - might provide a blueprint for a quantum computer; "the most
exciting prospect of all," he enthuses.