Treating Premature Ejaculation with Dapoxetine

Premature Ejaculation (PE)

Although PE is one of the most common male sexual disorders, it remains widely under-diagnosed and under-treated. Most physicians do not screen for PE and patients are extremely reluctant to talk about the condition with their partners or health care professionals. PE can have a significant impact on many aspects of a man's life. It can affect his and his partner's sexual satisfaction and their ability to build and maintain relationships – both sexual and non-sexual – and can impact a man's general sense of self-confidence.

An observational study published in the May 2005 issue of The Journal of Sexual Medicine found that patient-reported outcome measures (PROs), such as control over ejaculation, satisfaction with sexual intercourse and distress are important factors in assessing the benefit of treatments for PE in clinical studies. The study found that men with PE and their partners reported higher ratings for interpersonal difficulty, lack of control over ejaculation and dissatisfaction with sexual intercourse.

Data presented on May 23 demonstrates that men taking dapoxetine hydrochloride (see chemical structure above) for the treatment of premature ejaculation (PE) experienced significant improvements in sexual function, including ejaculatory control, satisfaction with sexual intercourse for men and their partners, and increases in intravaginal ejaculatory latency time (IELT). The U.S. Food and Drug Administration is currently reviewing a New Drug Application for dapoxetine, which if approved, would be the first prescription product indicated for the treatment of PE. These data were presented at the 100th Annual Scientific Meeting of the American Urological Association.
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