David Bradley, Actor

All the world’s a stage, and we are merely players. But, some of us play more than others. Take yours truly for instance, David Bradley Science Writer, also known as David Bradley Lover, Player, Puller, Guitarist, Photographer, Singer (but thankfully not Killer, see BBC news recently). I like to play with extramural pages on the Sciencebase website, creating little vignettes outside the conventional science blog. One of the aims is to ensure that my rather common name is seen more widely in the context of my website rather than web surfers heading elsewhere.

Of course you may actually be looking for the Shakesperean actor David Bradley who most famously plays Argus Filch in the Harry Potter movies. It’s rather a peculiar coincidence that David Bradley the actor is a member of the RSC (Royal Shakespeare Company) as David Bradley Science Writer is also a member of  the RSC (Royal Society of Chemistry). [UPDATE: I met that David Bradley in a pub once, he told me had had my book and we swapped autographs.

Of course, you may be looking for the other David Bradley actor, known now as Dai Bradley (because of Equity rules) who played Billy Casper in Ken Loach’s movie Kes, adapted from the story A Kestrel for a Knave.

So, here’s the link to Filch the actor – http://www.imdb.com/name/nm0103195/

and here’s the link to the Kes actor – http://www.imdb.com/name/nm0103193/

There may be other David Bradley actors out there and there may be other links on this page that are of more interest to anyone looking for information on David Bradley, either way, this has been David Bradley Science Writer playing.

This post may have appeared long before 8th January 2009, but that’s the most recent timestamp I have for it in the archives, so that’s the date it gets in the blog.

Scientists on Twitter


I carried out a little ad hoc experiment in social media this week. Having backed up my twitter friends and followers using Tweetake, I figured it was time to make them earn their keep…I jest. No, seriously, I’d downloaded the lists, which come as CSV files you can open in a spreadsheet program, and just for fun I thought I’d sort them into groups, picking science-related tweeps as the first category. By, pure chance, there were 100 scientific twitter users in that list.

Next, step was to cut and paste this list into my blog software and activate the web addresses for these 100 scientific tweeters. I then, of course, posted a tweet to let everyone know I’d compiled a list of twitter users with a scientific bent. Several people retweeted my tweet and I started to get some nice responses, direct messages, blog comments, and emails. Some of these came from twitter friends who had been inadvertently left off the list, so I added them and also activated their twitter name in the list, making it linkable to their twitter profile.

That move then formed the basis of a nice trade – you retweet or comment on the list and I’ll add you if you’re aren’t already on it and if you are I’d activate your twitter name and so it grows. I’ve not counted how many times it has now been mentioned, suffice to say that my local twitterhood continues to grow. Moreover, those people I listed are getting more followers and growing their own twittersphere as well as gaining traffic (several hundred new readers for some) from other social media sites that got into the loop, including StumbleUpon.

So, not caring what Bryony Garden thinks, it was Thursday that I coined a word to describe the scientwisters. That seemed to give the page a new boost in terms of visitors and retweeters.

For those interested in just how much impact this little project has had on my twitterhood. Here’s the twitter counter chart for the last week. The original post ran late on January 5 and was retweeted by various tweeps and scientwitters on the 6th. The chart below is now very out of date, sciencebase now has almost 3500 followers on twitter, partly due to this experiment, and partly thanks to Andrew Maynard’s Mashable article and Guy Kawasaki’s retweets, as well as the (re)tweets and shouts outs of countless scientwific friends on twitter.

twitter-counter-chart

It seems that I’m also a member of the twitterati, at least in Cambridge, UK, where, according to Twitter Grader, I am #4 below Bill Thompson, Vero Pepperrell, and Patrick Haney who is notasausage. Also seem to be doing well on twitterholic.

If you’re a scientific twitterer, let me know, either follow me on twitter itself, comment on this post or the original 100+ scientwitters page, or better still, tweet about the list. In return, I’ll add you to the list so we can expand this scientific twitterhood far and wide. By the way, there are now 400+ scientific twitter users on on my list and its still growing.

Alchemical Start to the Year

The Alchemist took a seasonable tipple over the holiday period but discovered that he needn’t have splashed out on all that expensive wine thanks to the field effect. He also discovers that all those spent coffee grounds he produces could be harvested to make biodiesel and hears of plans to rejuvenate the Baltic Sea with a giant fish-tank oxygenator. Drug users could soon be spotted by their glowing fingerprints, thanks to the latest development in forensic chemistry while a detector for melamine could help prevent future food scandals where this compound has been used illicitly to artificially inflate protein readings on baby milk and pet food. Finally, this week’s award could help boost European research in nanomedicine.

You can read all the headlines and straplines in the current issue of The Alchemist on ChemWeb.com

Oxytocin Facial

Oxytocin structureOxytocin, the nurturing hormone involved in child-birth and breast-feeding, apparently plays a role in how we recognize faces, according to a paper in the Journal of Neuroscience. Researchers gave volunteers a nasal dose of oxytocin and found that they all had improved recognition memory for faces, but not for inanimate objects.

In humans, oxytocin, which comes from the Greek meaning “quick birth”, increases social behaviors like trust, but its role in social memory has been unclear. “Recognizing a familiar face is a crucial feature of successful social interaction in humans,” said Peter Klaver, of the University of Zurich, Switzerland. In this study undertaken with Ulrike Rimmele, of New York University and colleagues, the team investigated for the first time the systematic effect of oxytocin on social memory in humans.

“This is the first paper showing that a single dose of oxytocin specifically improves recognition memory for social, but not for nonsocial, stimuli,” said Ernst Fehr, who has studied oxytocin’s effect on trust and is unaffiliated with the new study. “The results suggest an immediate, selective effect of the hormone: strengthening neuronal systems of social memory,” Fehr said.

Reflecting on Climate Change

Global Warming
A radical plan to curb global warming and apparently reverse climate change caused by our rampant burning of fossil fuels since the industrial revolution would involve simply covering large areas of the world’s deserts with reflective sheeting.

The idea is discussed in detail in the January issue of the International Journal of Global Environmental Issues and was reported widely in the press and across the blogosphere over the holiday period. Is it so much science fantasy or might it actually work? Engineers Takayuki Toyama of company Avix, Inc., in Kanagawa, Japan, and Alan Stainer of Middlesex University Business School, London, UK, suggest that there is too much pessimism around concerning our ability to realistically reduce atmospheric carbon dioxide levels so other measures may need to be taken.

Reader Thomas Hewitt emailed his concerns about the proposal, he was worried that reflective sheeting would be expensive and intrusive and points out that diluted white latex paint can increase the reflectivity of porous surfaces, such as concrete, by ten percent. “An even better deployment [than painting desert rocks], would be to use it on manmade surfaces, in hot areas,” he says, “Locally, this could be seen as a rollback of the urban heat island effect. If done to enough surface area in high insolation areas, it might have a noticeable effect on global temperatures.”

I asked Toyama about the viability of the team’s proposals. Is it ever likely to be viable to cover such large areas of the desert with reflective sheets weighted down with sandbags? “Yes it is viable,” he says, “We are often questioned if the area we propose is too small! Of course, compared to the surface area of the earth, it is fairly small.”

But, how will such sheets be kept clean and maintained? And what will stop them being covered with dust in a desert? “The sheets would be laid in dry desert, with little rainfall, remembering that half the world’s desert area is composed of rock,” he adds, “Two known relevant examples come to mind: the NAZCA Lines in Peru have been unpaved for 1000 years and the successful covering sheets over snow in the North of Japan to reserve snow for summer skiing. Of course, the issue of maintenance work for sheets preservation needs to be investigated this would certainly provide jobs and benefit the area.”

But, couldn’t the problem be solved by every household simply painting their roofs white instead? “Roof area would be insufficient and would contribute a small percentage,” he added, “However, as a supplemental solution, it would be helpful in contributing to energy saving to cool rooms. Indeed, this is already used in flat-roofed houses of rich people in Middle and Near East. In Japan, it is seen as effective in improving family comfort but is not perceived as sufficient to tackle global problems.”

It still seems as far-fetched a macro-engineering project as subliming millions of tonnes of carbon dioxide at the bottom of the oceans. However, Toyama suggests that this is an unfair comparison. “Our concept is basically to alter the flow of heat whilst subliming relates to treating carbon dioxide stock problems itself, not a well established, suspicious and unreliable technology from the safety angle. As an overview, in management of technology terms, there must be a multi-faceted bold approach to carbon dioxide reduction or the target set of 50% by 2050 at the Touyako Summit will never be reached.”

The obvious thing to note of course, is that surface albedo changes are not a complete replacement for greenhouse gas reductions, adds Hewitt. “For one, the distribution of the cooling effect will never be a good match to the warming effects of greenhouse gases,” he suggests, “Secondly, we still have the serious issue of ocean acidification. The key trick (if cooling via deliberate surface albedo intervention is technically doable), will be to prevent it from being used an excuse to continue business as usual emissions.”

The team’s paper was apparently submitted in order to respond to current discussions about how a more cosmic view of Earth’s energy balance might be addressed regarding human activities. “Carbon dioxide reduction is insufficient from such a viewpoint,” Toyama adds.

Research Blogging IconTakayuki Toyama, Alan Stainer (2009). Cosmic Heat Emission concept to ‘stop’ global warming International Journal of Global Environmental Issues, 9 (1/2) DOI: 10.1504/IJGENVI.2009.022093

Leukemia Tweezers

stained-leukemia-cellsThe first 2009 issue of SpectroscopyNOW is now available:

Tweezing out leukemia spectra – US researchers have used laser tweezers Raman spectroscopy (LTRS) to help them characterize the effects of different chemical fixation procedures on the spectra of healthy cells and leukemia cells and to avoid the misinterpretation of data.

Crime and punishment – A truly interdisciplinary collaboration between biology, law and neuroscience at Vanderbilt University has used functional magnetic resonance imaging, fMRI, to watch how the brain changes when a person thinks about crime and punishment.

Folding issues – NMR spectroscopy is helping US chemists work out shorter and simpler routes to protein-based drugs for treating a wide range of illnesses including diabetes, cancer, and hepatitis.

By Jove, it’s hot and steamy – In 2007, astronomers discovered that a scorching-hot gas planet beyond 63 light years from our solar system is steaming with water vapour, now, it seems the planet, a hot Jupiters, also suffers from high carbon dioxide levels in its atmosphere.

Opal reversal – Electrochemically oxidizing and reducing an inverse polymer-gel opal causes it to swell and shrink, which alters the wavelength of the light it diffracts brightly, from ultraviolet through the visible to the near infrared, the material could pave the way to new display and monitor technologies.

X-rayed dinobird – Researchers at the SLAC National Accelerator Laboratory used the Stanford Synchrotron Radiation Lightsource (SSRL) to shine intense X-ray beams on the so-called “dinobird” to reveal chemical secrets that have been hidden from view for millions of years.

How Alternative Medicine Fails Us

rhodiola-roseaI’m forever fending off the alternative medicine brigade who seem to clump around this website and email me all kinds of supposed miracle cures that will spell the end of all health ills. One herbal remedy I recently focused on is Rhodiola rosea, in which I critiqued a promotional email from a vested interest in the product. They made all kinds of claims for this material on the back of very limited clinical trials. Needless to say advocates of alternative medicine commented aplenty.

As a chemist, I take what I hope is a healthy and skeptical view of all the biochemical and physiological claims these people make for their products. I’m just worried that there are so many people who are perhaps desperate to fix their lives that they become easy prey for such marketing. Anyway, for those who feel a chemist has no place criticising their beloved remedy, I turned to a pharmaceutical expert in Sheryl Torr-Brown of the Future Trends in Health blog to provide some additional support for my argument. She has many years experience in pharmaceutical science and has no axe to grind and offers an honest appraisal of my original post and some of the comments left by Sciencebase readers.

A glance at the scientific literature covering this herb seems to be minimal and biased in the main, she told me, and as such she agrees with my argument.

“When dealing with alternative medicine,” she says, “it is not enough to be right if you want to avoid the attacks. You also have to be sensitive to the highly personal views of those who find benefit in the drug albeit most likely due to placebo effect.”

This is perhaps an important point. Yes, the placebo effect is valid, but these remedies are usually very expensive and people are often spending their hard-earned money on what amounts to sugar pills, something that should be avoided perhaps especially in the current economic climate when every penny counts.

“A major point that most of the non-scientific public do not understand is that there is no such thing as a safe drug, natural or not,” adds Torr-Brown, “The dose is the poison, as the father of modern toxicology, Paracelsus said in the fifteenth century. Anything and everything will be toxic if you have enough of it or it gets into the wrong place. Unfortunately, people are tired of Big Pharma advertising and the media frenzy around drug withdrawals.”

She points out that ‘natural’ is sounding better and better to many folks, despite the existence of natural belladonna, natural cobra venom, oh, and natural background radiation. In the age of the Internet, it is now very easy to get positive anecdotes about anything. “Basically, one can decide what one wants to believe and then go find the evidence to support it,” Torr-Brown adds, “For scientists, we look for controlled studies to prove a point, whereas the general public are happy with a personal story or two of success.”

Many people, including several of the original, negative commenters on my R rosea post, are grasping to find something that works for them. “You cannot discount [some of these views] from a human perspective, but it makes no sense scientifically, adds Torr-Brown, “I am shocked by the number of people I know who pay huge amounts of money for the latest panacea only to give it up after a couple of months, usually due to lack of interest.”

  • Innocent children and the most vulnerable can be hurt the most
  • £200m boom as demand for ‘natural’ cures soars
  • Rhodiola rosea
  • How not to do a study on the efficacy of “alternative” medicine
  • Rhodiola rosea

K Barry Sharpless Live

A recent live Webcast gave Professor K. Barry Sharpless, the 2001 Nobel Prize Winner in Chemistry, the opportunity to explore the intricacies of scientific discovery and how it is that when observation is concerned, good luck favours only the prepared mind.

Video no longer available, sorry.

Neither the video nor the sound quality were great anyway. The organisers also ran a one-on-one interview with Sharpless. You might have also watched student reactions to the Sharpless lecture.

New Year Science Books

If you’re New Year’s resolution is to read more books, then check out the latest additions to my bulging shelves, order them quickly on Amazon and you may just have them in time to fulfill that New Year’s resolution:

Experimental heart – a racy read set in the world of pipettors and gene splicing, a first novel by Jennifer Rohn. creator of LabLit.com who blogs on Nature Network at Mind the Gap. Richard Grant has a more substantial review of Dr Rohn’s book under the title: I’m a professional cynic but my heart’s not in it.

Mars 3-D by Jim Bell – does what it says on the tin, super 3D images of the Red Planet with a free set of red-green spectacles, my kids were very impressed.

Exploring the Mystery of Matter – ATLAS – a gripping read of what we can expect once the LHC experiment is finally up and running.

Hubble – Imaging space and time – the most cosmic coffee table book you could ever wish for from National Geographic

The Science Book – also from NG, this mighty tome tells you “everything you need to know about the world and how it works, would make a fantastic gift for a homeschooler.

Also for review this week is yet more cosmic stuff this time on DVD: “The Universe” (they don’t for small-scale names these days, do they?) Complete season 2 of the History Television Network rroduction (five DVDs)

Vote for Sciencebase

UPDATE: Sciencebase was placed third in the Shorty Awards science category, apparently that gets me a free ticket to the awards ceremony, but unfortunately won’t pay my airfare or accommodation…regardless thanks for all your nominations and votes!!!

Sciencebase is currently #4 #3 in the Shorty Awards science category, please check out the site and if you think it worthy give us your vote via the awards nomination page or on Twitter.

The Shorty Awards honour the world’s top Twitterers in a variety of categories.

Here’s what nominators have said about sciencebase so far:

“I want 2 nominate @sciencebase in #science, b/c how can u get round twitter sciencebase in this category? He’s gr8 & has wit!” – @laikas

“I nominate @sciencebase for a Shorty Award in #science because he keeps his hand on pulse of science.” – @freesci

“I nominate @sciencebase for a Shorty Award in #science because he’s informative, witty, relevant and kind.” – @Jennifer_P

Your vote would be much appreciated!