Herbal Highs and Lows

Structure of cathinoneOnce again, the BBC is reporting on herbal highs. This time, it tells us that while most legal high pills are based on a group of drugs called piperazines, of which BZP (benzyl piperazine) is the most common and will be banned in the UK under a European directive, it is cathinone, the active ingredient in the plant khat, a widely used stimulant in East Africa that is the focus of today’s news. Cathinone is beta-ketoamphetamine.

Although so-called “legal highs” are marketed as a safe alternative to illegal, classified drugs, they are not without risks. “A high heart rate, high temperature, high blood pressure, and more severe effects such as heart attacks and strokes,” can happen, consultant toxicologist Paul Dargan, clinical director of the Guy’s and St Thomas’ Poisons Unit London, told the BBC.

Worryingly, there various legal herbal highs available that claim not to contain the likes of BPZ, but toxicologists frequently find these potentially lethal compounds in such products.

There a dozen compounds being black-marketed widely, the law hasn’t caught them all yet, but, says the BBC, legal doesn’t mean safe.

Nobel Prize for Physics 2008

The Nobel Prize for Physics 2008 is announced here Tuesday, October 7.

The Nobel Prize in Physics goes to Yoichiro Nambu (born 1921) of the Enrico Fermi Institute, University of Chicago “for the discovery of the mechanism of spontaneous broken symmetry in subatomic physics” and to Makoto Kobayashi (b. 1944) of the High Energy Accelerator Research Organization (KEK) Tsukuba, Japan, and Toshihide Maskawa (b. 1940) of the Yukawa Institute for Theoretical Physics (YITP), Kyoto University Kyoto, “for the discovery of the origin of the broken symmetry which predicts the existence of at least three families of quarks in nature”. You can read the full press release from the Nobel org here.

As I mentioned in my previous post on the 2008 Nobel Prize for Medicine and Physiology item, yesterday, the team, led by Simon Frantz have been using modern web 2.0 type technologies, including RSS and twitter to get the word out to journalists as fast as they can. Part of the reason, apparently, was to save journalists from suffering serious F5 button finger strain at announcement time.

Anyway, here’s the twitter update page – Nobel tweets. They also created a neat little widget so that we could embed the timetable into a website (see left). As you can see, the 2008 Nobel Prize for Chemistry will be announced Wednesday October 8. I’m hoping once again for some straight chemistry, rather than bio-flavoured molecules, as this will give me a chance to get my teeth into my journalistic alma mater as it were.

Mobile Internet Insecurities

ipv6-readyMost internet users will be unaware and unconcerned by the computer science and technology that underpins their daily web surfing, emails, chats, and Twitter updates. But, there are, of course, thousands of incredibly bright people working behind the scenes to make the internet work. One aspect of the backroom work that goes on, is the development of the software systems that carry the packets of information across the internet, whether that’s to open a web page in your browser, connect your net phone to a friend across the ocean, or trap spam on its way to your inbox.

At the moment, the internet is mainly running on a system known as Internet Protocol version 4, or IPv4. Version 4 was first mooted in 1981, years before the Web was invented and certainly long before broadband, Youtube, MySpace, Facebook, Twitter, and VoIP entered the public consciousness. What IPv4 does is to try and deliver the packets of information across a network. It’s imperfect, because it doesn’t ensure the packets are delivered in the right order, or even that they are delivered at all. In fact, it is known technically as a “best effort” protocol. As such, IPv4 requires another layer over the top of it that makes sure all packets are delivered and sorts them into the correct order before they are used to render a web page, download an email, or Tweet that Plurk.

Another disadvantage of IPv4 is that it can handle a mere 232 addresses. That may seem like a huge number, but work it out and it actually only comes to well over four billion. However, with billions more people on the planet, millions of organisations, collectives and companies, one can see that 232 is rather a small number if everyone wants an internet address.

IPv5 IPv6, Internet Protocol version 6 hopes to remedy all these problems. First off, it can handle 2128, that’s about 3.4×1038*, internet addresses. Even with population growth the way it is, we are unlikely to ever need quite so many addresses, at least in the foreseeable future. Moreover, this added addressing capacity solves in one fell swoop almost all the network management and routing issues seen with IPv4, which means once it is widely adopted the whole of the internet will be rendered much, much more efficient.

However, while IPv4 has been in place for decades and IPv6 is not even quite fully packaged up and ready for delivery, researchers are already spotting security flaws in IPv6. Writing in the International Journal of Internet Protocol Technology, a team in New Zealand has highlighted several security issues that developers and device users may face once IPv6 goes online, particularly across the mobile internet. With every third person using a Blackberry, an iPhone, a Google Android phone or similar, mobile security will soon rise to the top of the agenda for hackers, crackers, and those who seek to defeat them.

Michael Dürr and Ray Hunt of the Department of Computer Science and Software Engineering, at the University of Canterbury, in Christchurch, New Zealand, explain that in parallel with the design and development of IPv6, run several protocol extensions for mobile support, which are labelled MIPv6.

Over the last decade, access network technologies available to connect stationary as well as mobile devices to the internet have reached a remarkable diversity. Wireless systems such as Bluetooth, 802.11x, GSM, UMTS and WiMAX have shown very significant development and each individually can provide reasonable internet connectivity with more or less acceptable data rates.

However, the different characteristics of each technology means that an overarching MIPv6 to unite them all in a way that is transparent to users is now needed. Sciencetext has previously covered the issue of connecting 3G devices to wi-fi networks for instance. Such unity in always-on connectivity across disparate, interwoven networks, brings new security challenges not yet addressed by the underlying protocols. The various insecurities all boil down to attacker Charlie eavesdropping on Alice and Bob, sabotaging their connection, changing the information being sent between Alice and Bob, or causing a denial of service to prevent Alice and Bob communicating at all. The various insecurities fall into the following categories all of which are technically feasible with the current state of MIPv6:

  • Address theft is a security attack where Charlie pretends to be a certain node at a given address and attempts to steal traffic from Alice destined for Bob.
  • Secrecy and integrity attacks involve Charlie pretending to be Bob and intercepting the new connection between Alice and Bob and possibly changing the information being sent between Alice and Bob.
  • Replay attacks involve Charlie impersonating a mobile node and redirecting Alice and Bob’s traffic with malicious intent.
  • Flooding attacks involve Charlie redirecting traffic from one or more nodes to an arbitrary internet address.
  • Binding update attacks let Charlie exploit the strong authentication mechanisms in the IPv6 technology to trigger a denial of service (DoS) so that Alice and Bob can no longer connect.
  • Reflection attacks trick suitable nodes, called reflectors, into sending data packets from Alice and Bob to Charlie’s address.

Some threats will remain too expensive for the cyber-saboteur to consider, but intrinsically, “IPv6 cannot guarantee overall security due to its inherent architectural characteristics,” the researchers explain:

IPv6 (as well as its predecessor, IPv4) are based on a routing infrastructure, that must be trusted. The protocol itself can only be regarded as secure as the routing infrastructure constituting the internet.

By highlighting the insecurities of MIPv6, the researchers hope to provide insights into how risks and potential attacks could be limited. “Some security risks can only be mitigated, but not completely removed,” they say.

Michael Durr, Ray Hunt (2008). An analysis of security threats to mobile IPv6 International Journal of Internet Protocol Technology, 3 (2) DOI: 10.1504/IJIPT.2008.020468

*3.4×1038 is the number 34 followed by 37 zeroes: 340,000,000,000,000,000,000,000,000,000,000,000,000 (340 billion, billion, billion, billion)

Nobel Prize for Medicine 2008

This year the Nobel committee has awarded the Prize for Physiology or Medicine to Harald zur Hausen for his discovery of human papilloma viruses (HPV) causing cervical cancer and to Françoise Barré-Sinoussi and Luc Montagnier for their discovery of human immunodeficiency virus (HIV). The announcement was made via the Nobel organisation’s Twitter page and on their site.

zur Hausen (born 1936) works at the German Cancer Research Centre Heidelberg. Barré-Sinoussi (born 1947) is at the Regulation of Retroviral Infections Unit, Virology Department, Institut Pasteur Paris, France and Montagnier (born 1932) is at the World Foundation for AIDS Research and Prevention also in Paris. The full press release for the announcement of the Medicine Prize is here. Where’s Robert Gallo in all this one wonders?

You can get up to the minute alerts on the chemistry, physics, and other Nobels announced later this week via the Nobel site and their new alerting systems with SMS, RSS, Twitter and more (thanks to new publicity guy and friend of Sciencebase Simon Frantz and his colleagues).

nobel-medalYou can find the iGoogle gadget for the Prizes here. There’s a news widget here and the Nobel RSS is here.

Physics is announced October 7 (dark energy/dark matter perhaps?), Chemistry (another aspect of biology, no doubt) October 8, Literature on Thursday, we give Peace a chance on Friday, finally the Economics Prize on Monday 13th (hopefully it won’t go to a merchant banker, given the state of the global economy at the moment). You can get a list of past winners of the Nobel Prize for Medicine here and the Nobel announcement here.

Chillis and Cancer

Capsaicin structureIf you’ve ever worried that a steaming hot bowl of chili or cajun chicken might be doing you more harm than good, then you’re not alone. Research earlier this decades pointed out that capsaicin (the “hot” compound in red hot chili peppers) and safrole (the hot molecule in black pepper) could both be carcinogenic.

Thankfully, for lovers of Mexican-American, Cajun, white Creole, black Creole, spicy Indian food, Malaysian, Thai etc etc…the opposite seems to be true. It is more likely that compounds found in spicy foods are good for us. One might wonder how such cuisine could have persisted for countless generations if they weren’t good for us. After all the news just in on saturated animal fat is that even it is better for us than the last 20 years of health scaremongering would have you believe and we have been eating that for countless, countless generations.

Anyway, the BayBlab submission to the Cancer Research Blog Carnival #14 hosted on Sciencebase today, cites the various compounds in spices that are thought to have health-giving properties. These include turmeric (curcumin), red chili (capsaicin), cloves (eugenol), ginger (zerumbone), fennel (anethole), kokum (gambogic acid), fenugreek (diosgenin), and black cumin (thymoquinone). The ability of all these compounds to prevent, rather than cause, cancer has apparently now been established.

So, with your health taken care of, it’s time to turn up the heat and tuck into that chili bowl with a smug, if scorched, look on your face!

Cancer Research Blog Carnival #14

cancer research blog carnivalI don’t know anyone who hasn’t got a cancer story to tell, whether it is personal experience, a relative or friend, or association with their patients or through their research.

Cancer has always been with us, but contrary to the popular image propagated by the mainstream media it is not a simple, nor single disease. In this month’s cancer research blog carnival hosted on the Sciencebase Science Blog, I present a few selected posts from fellow bloggers discussing various aspects of cancer research. Thanks to everyone who submitted a cancer research post.

First up is PalMD on the Denialism blog who explains that cancer is the second leading cause of death, in the US at least, and confirms the ubiquity of the disease as 4% of the population is directly affected (think six degrees of separation type networks to see how almost all of us can have a cancer story to tell). The post provides answers to some of the LAQs (least asked questions) and FAQs (frequently asked questions about cancer. A post from Stephan Grindley augments the cancer 101 with a straightforward commentary on breast cancer prevention and detection.

According to Charles Daney on Science & Reason, recent studies are making it increasingly apparent that cancer is really many different diseases and he explains how this means a new approach to understanding cancer at the molecular level.

More particularly covering cancer research, GrrlScientist offers an interesting take on the genetics of colour and cancer in Behold The Pale Horse and BayBlab discusses a recent publication in the journal Science on the subject of trans splicing and chromosomal translocations as well as the connection between chilis and cancer – preventative or protagonist?

HighlightHealth, meanwhile, discusses the implications of a large-scale, multi-dimensional analysis of the genomic characteristics of glioblastoma, the most common primary brain tumour in adults. On Hematopoiesis, we learn how travelling normal and malignant cells decide where to stay and on get linked up to five great talks from the experts.

Cancer vaccines are big news and none more so than the vaccine being offered to young girls to protect them from cervical cancer caused by HPV. Health blogger Grace Filby has posted on why this vaccination campaign is not a good idea given the lack of safety data currently available.

Orna Ross tells us about the good things she has gained from having cancer/ and points out that fighting cancer as if it were a battle is not the only approach to tackling the disease. Actorlicious meanwhile provides a star-studded perspective and how the famous and infamous are standing up to cancer.

A post from the University of Oxford science blog on exploiting the Achilles’ heel of cancer, describes how a new approach will lead to treatments with none of the common side effects of cancer therapy. And, Sally Church on the Pharma Strategy blog asks will Abiraterone impact survival in advanced prostate cancer?, the most common carcinoma in men. She also provides a fascinating insight into treating triple negative breast cancer.

Science Metropolis discusses how public health expert Dave Ozonoff hopes to use mathematics and chaos theory to explain paradoxical cancer frequencies, such as those seen in Cape Cod, where rates are 25% higher than the state average in Massachusetts.

Finally, one from the recent Sciencebase archives entitled (hopefully quite controversially) alcohol causes cancer.

Visit the Cancer Carnival site to read past carnivals, to get information on scheduled posts and to find out how to host your own cancer research blog carnival.

Melamine Contaminated Food List

melamine-candy via LA TimesBefore you check out the following items, please click here first to grab the Sciencebase newsfeed. I’ll be updating the melamine news over the next few days, and the RSS newsfeed system allows you to keep up to date with the Sciencebase site without having to check back by adding our headlines to your Google account, My Yahoo, Bloglines or your active bookmarks in your browser.

As the melamine in milk products from China problem continues to grow apace, Sciencebase presents a succinct list of melamine contaminated food list culled from the most recent news results on the subject. This is by no means an exhaustive list nor is it a condemnation of any particular products, it’s here merely to raise awareness of what is happening with regard to the melamine in milk scandal.

  • Powdered baby milk.
  • HK finds melamine in Chinese-made cheesecake.
  • Cookies With Melamine Found in Netherlands.
  • Mr Brown coffee products.
  • Manufacturing giant Unilever recalls melamine tainted tea. CNN is also reporting that the Hong Kong authorities Sunday (October 5) announced that two recalled candy products made by British confectioner Cadbury had high levels of melamine.
  • Melamine Detected in Two More Ritz Snacks.
  • More Chinese-made sweets recalled in Japan.
  • White Rabbit brand Chinese candy contaminated: Asian health officials.
  • Lipton, Glico and Ritz the latest businesses to be affected by milk powder scandal.
  • Hong Kong finds traces of melamine in Cadbury products.
  • Recalled Melamine Milk Products include Asian versions of Bairong grape cream crackers, Dove chocolate, Dreyers cake mix, Dutch Lady candy, First Choice crackers, Kraft Oreo wafer sticks, M&Ms, Magnum ice cream, Mentos bottle yoghurt, Snickers funsize, Yili hi-cal milk, Youcan sesame snacks and others. Testing of some of those has already proven negative.
  • Melamine Found in More China-Made Products, including Heinz DHA+AA baby cereal.
  • 305 Chinese dairy-based products temporarily banned in Korea.
  • US bloggers have gone so far as to uncover dozens of products recalled in China that were still on the shelves of their local supermarkets.
  • 31 new milk powder brands found tainted.

Just for the record, this is not, as was suggested on a couple of blogs linking here, a definitive, complete list. I will update it as and when new information comes to light. Check out the previous posts for more information in the background to this news story and for further discussion on the issues surrounding the melamine in milk products scandal: Melamine Scandal Widens and (2008-09-29) Milky Melamine.

Double Tennis Racquet Racket

two-racquet-tennisI’m not sure what to make of this, but Don Mueller, of William Paterson University, New Jersey, who goes by the nickname Dr Bones sent me some video clips of what is, essentially, a new sport he invented – two-racquet tennis. Now, my first thought was: “what the flip?” But, apparently his service velocity is higher than that of most tennis professionals, although I don’t think that has anything to do with using a racquet in each hand.

Anyway, he has posted a selection of videos on Youtube to demonstrate his prowess at this new sport:

Tennis Serve (a), Tennis Serve (b), Groundstrokes (a), Groundstrokes (b), Drills-righthand (a), Drills-lefthand (b)

Mueller tells me that he combined his understanding of basic physics to devise the “Whip-Grip”, which gives him the higher velocity. He says there are other advantages of playing tennis with a racquet in each hand: “It’s really great at the net and no more tennis elbow pain from hitting backhands, the cause of most tennis injuries,” he explains, “Where most people say, Why?, I say, Why not?”

Mueller is a teaching adjunct at WPU and this semester he tells me he’s teaching mathematics. “I’ve taught chemistry, physics and math at WPU and that’s the way I like it,” he says, “With a PhD in chemical physics, I enjoy teaching all of these subjects. Not being tied down allows me to do other things, which in my case means performing science and health shows for the public along with my promotion of two-racquet tennis.”

The notion of reinventing a well-known and popular sport by the novel application of physics is not entirely new. Just think of the football (soccer) players on the fields of Rugby School in England, when William Webb Ellis during the early nineteenth century famously made the ball defy gravity and invented the eponymous team sport – rugby – from which American football was ultimately to evolve. Perhaps in 100 years’ time two-racquet tennis will have its own name, ambibat, perhaps and be just as common. One has to wonder how a McEnroe of the future might cope though, with two racquets to fling at the umpire!

Melamine Contaminated Milk

chinese-boyA brief summary and update to the Sciencebase original posts on Melamine in Milk and Melamine Scandal Widens.

Dairy farmers have been feeling the squeeze for years, particularly in parts of the world where technological advancement has been slow in coming and so their profit margins on their milk output have not been lifted by improved efficiency. In order to boost profits milk has been diluted. However, this brings with it the problem of falling quality – dilute with water and measurable concentrations of milk proteins, fats, and sugars fall. Dilution by up to 30% has not been uncommon, which is where melamine (as I’ve mentioned) comes in. Melamine is a small organic molecule with a high nitrogen content that can easily fool the quality control equipment into thinking that nitrogen (from protein) is present at normal levels and so the milk is passed as good.
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Unfortunately, it is possible that melamine accumulates in the body and causes toxicity problems – basically damaging the kidneys and forming stones (solid deposits within the kidneys or bladder). Infants fed regularly with milk containing melamine will be particularly susceptible to these effects. As we have seen tens of thousands have been affected and several have died in China. Why this problem is not more widespread, given the rather large number of infants potentially having been drinking contaminated formula-milk for months is unclear.

Hsieh Teh-sheng, director of the Taiwan Urological Association and chief of Cathay General Hospital’s Department of Urology told the Taipei Times, that while there is no direct toxicity information on melamine’s health effects on people, the level of melamine found in the milk products is “not particularly high”. He says that kidney stones or other effects blamed on the melamine “could just as easily be caused by other harmful chemicals,” which is a point I discussed in the original post.

However, cyanuric acid is often present in melamine samples and the two can react together to form crystals, which can form stones. The current scandal could, whatever the final outcome, provide researchers with useful data on the effects of chronic exposure to melamine and its toxicity to the kidneys and bladder.

Sources in China have now said that Sanlu, which is at the heart of the controversy, was aware that its products were contaminated with melamine as long ago as December 2007. Fonterra, the New Zealand dairy company and 43% stakeholder in Sanlu claims to have approached the Chinese authorities as soon as it heard about the problem but was held back from going public because of the imminent Beijing Olympic Games. One can imagine there were additional pressures that prevented Fonterra from pushing for a solution. But, it cannot blame Chinese regulations for it failing to warn consumers as soon as it knew about the contamination.

Products across the globe containing milk imported from China seem to have been affected and authorities from Australasia and Asia to Europe and the US are withdrawing formula milk, coffee and tea drinks, candies, soup, cheese powder, biscuits, ready-made desserts, and chocolate. however, there are calls from some commentators that the US Food and Drug Administration (FDA) should be more forthright on its recommendations for consumers concerned with the melamine in milk scandal.

For those thinking of testing the products in their store cupboard, there’s a Craigslist item for sale here. It’s described as a “Rapid Melamine test kit—AgraQuant Melamine ELISA test kit”.

But, before you grab your credit card, think carefully whether you’d like to make ELISA (Enzyme-Linked ImmunoSorbent Assay) your friend. It’s a tricky test and probably not one you could rattle off in an afternoon with at least some biomedical background. Also, there’d be no point in testing your Ikea furniture for melamine, the “Melamine” they use is a polymer resin (a plastic, in other words) made from the small organic molecule melamine and formaldehyde, and no there’s no need to worry about using melamine cooking utensils or eating off a melamine-coated kitchen table.

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Disastrous Rumours

rumoursGossip and rumours, they are the life force of cultural interaction. Just ask Guy Kawasaki, whose Truemors.com website took off last year, the hundreds of hacks who peddle the minutiae of celebrity lifestyles complete with the Photoshopped products of the paparazzi, or Perez Hilton. But, there is a serious side to rumours. In the midst of a natural disaster, terrorist atrocity, or war-torn location, the spread of rumours can mean the difference between life and death.

Informatics and e-business expert Judith Molka-Danielsen of Molde University College, Norway and public relations professional Thomas Beke of the University of Szeged, Hungary, explain how rumours affect how rational individuals assess risks, evaluate needs, and make decisions in disaster-affected environments. “Rumours play a confounding role in disaster management,” the researchers say.

In order to understand how rumours might propagate under extreme conditions and how a strategy to contain rumours, or enable “useful” rumours, to spread might be developed they have developed a definition of “rumour”. They point out that a rumour is essentially a message, but one with some degree of false content and a method of transporting the content. Two well-documented cases of technological and biological disaster events that led to loss of human welfare and economic losses and how the interplay of rumours in each cases underpinned the outcomes epitomise the definition: Chernobyl nuclear accident of 1986 and the tsunami that devastated Aceh in 2004.

Previous studies have suggested that immediately following a major disaster, “an atmosphere of fear, distrust and a scarcity of reliable information,” develops, within which people are “eager to circulate emotionally negative news, even if that news is exaggerated.” It is becoming apparent that relief agencies could use the rumour mill to spread accurate information to help those likely to be affected by a disaster rather than allowing the passive spread of misinformation to take place.

One might wonder whether such a positive rumour mill if it had been in place in China might have staved off the melamine in milk disaster that has been unfolding across Asia since well before the Beijing Olympics, now that tens of thousands of infants have been affected.

The researchers point out that no formal research has been presented to give relief coordinators a comprehensive understanding of the role of rumours in disaster management. There seems to have been no progress in this regard between major disasters and the relief efforts associated with them; erroneous and incomplete information exists in many real-world scenarios almost by default.

It is the imperfect state of information and its communication that are the fundamental preconditions in the birth of rumours. But rumours are something more than just misinformation and being misinformed. Rumours can have a viciously reinforcing and cascading affect on an existing state of falseness or existing communication problems. Disaster management agencies must therefore understand how to identify and address the phenomenon of rumours.

The team has developed a Rumour Object Enactment Model (ROEM), which defines the connections between different rumours and how they can affect the playout of relief work and human behaviour during a disaster. They used the cases of “Foot and mouth disease” (2001) and the “London underground bombings” (2005) for their detailed analysis to provide the underpinnings of their model.

Responsible agencies, the researchers suggest, could make use of their model to be able to identify how particular rumours start during a disaster and how they can be corrected or exploited to benefit those involved in the disaster.

It is essential for leaders, assistant groups or responsible authorities to understand the possible positive or potentially chaotic uses of rumours and the difficulty in predicting or controlling the boundaries of their dispersive domain. Decision makers with this knowledge will be better equipped to analyse the disaster environments and better able to respond to events in the presence of uncertainties.

Judith Molka Danielsen, Thomas Beke (2008). Rumours interplay in disaster management International Journal of Risk Assessment and Management, 9 (4) DOI: 10.1504/IJRAM.2008.020413