Don’t Poison Your Dog This Holiday

Theobromine structure

‘Twas the night before Christmas, when all through the house
Not a creature was stirring, not even a mouse

Well, that may not be quite true, do you know what your dog is doing right now? What about the cat? They’re not rummaging through the presents under the tree are they? You didn’t leave any luxury plain or dark chocolates under there did you? If you did, you could wake up to a quite horrible surprise when Christmas morning comes around. Chocolate makes pets ill! That’s the important seasonal warning being delivered by vets everywhere.

Poisonous chocolatesSo, what’s the problem? Surely a little chocolate snack in the night isn’t going to harm good-old Fido? Well, our vet begs to differ and so do the veterinary toxicology sheets for the chocoholics’ favourite fast-food. Man’s best friend, and several other animals, you see lack a particular liver enzyme that their owners do possess, that breaks down a toxin found naturally in chocolate – theobromine.

Theobromine has nothing to do with the element bromine, rather it is a bitter alkaloid from the seed of the cacao tree, known scientifically as Theobroma. The basic chemical skeleton is a xanthine unit, same one on which several other more well-known natural chemicals are based. The stimulant caffeine (from coffee beans) is a xanthine, for instance, so too is theophylline (found in tea and used in treating COPD and asthma).

Non-chocolate Labrador

Lacking the enzymes to metabolize theobromine leaves dogs exposed to the toxic action of the compound, which can cause vomiting, diarrhoea, hyperactivity, tremors, seizures, abnormal heart rhythms, and in extreme cases death.

So, what are the first signs of chocolate poisoning, what’s the lethal toxic dose, and what should you do if you think your dog has been at the chocolatier’s produce? Well, the first signs of chocolate poisoning are vomiting and diarrhoea, increased frequency of urination, and nausea. A toxic dose that will cause symptoms is about 100-150 milligrams of theobromine per kilogram of body weight, toxic dose could be approximately 250 and 500 mg/kg. A kilogram of milk chocolate will contain about 2 grams of theobromine. So a greedy, little dog is at greater risk of a serious digestive upset than a big gluttonous dog if he or she snaffles a 250 g bar of milk chocolate.

There is no direct way to treat chocolate poisoning in dogs, although inducing vomiting if the animal is caught “brown-pawed” (best left to the vet) is probably a good idea. A dog that has eaten a lot of chocolate will almost certainly require hospitalisation for at least the four days while the theobromine is naturally excreted (It takes about 17 hours for a dog to excrete half of the theobromine in its system, which means this toxin will reach vital organs repeatedly via the blood stream). But, who needs that, or worse, at Christmas? As they say: a gram of prevention is worth a kilo of cure.

For lovers of cats (small, domestic, big, wild) keep the aspirin out of reach. It’s deadly poisonous to felines.

December Chemical Discoveries

In addition to my interview with Chinese chemist Andrew Sun, mentioned earlier this week, the December issue of Reactive Reports features the pick of chemistry news

DNA nanorings DNA Nanorings  A simple approach to making rigid DNA nanorings with tailor-made functionality has been developed by Michael Famulok and his team at the University of Bonn, Germany.

Sunshine superpower Sunshine Superpower  In the depths of the Northern winter, as we approach the shortest day of the year, what could be more welcome than a little sunshine news.

ACS chemical discoveries of 2007 Five Firsts in Chemistry  With 2007 rapidly coming to an end, the inevitable lists are popping up. Not wishing to be left out this holiday season, the American Chemical Society has compiled a Top 5 from its own publications. Oh, and by the way, Sciencebase didn’t want to be left off the wish list either, so I did a Top Ten Molecules of 2007 item just recently.

Ten Computing Tips | Data Recovery

Faster Firefox

Seeing as the holiday season is fast approaching, I thought I’d offer an extra post covering some of the browsing and blogging tips and tricks I run on the Significant Figures site at Sciencetext.com. On that site I used to mainly discuss inappropriate unit conversions, sloppy statistical use, and dodgy typos in the media and still do occasionally.

For instance, there was a lot of press on the comet bigger than the sun issue recently, which interconverted miles and kilometres with astoundingly high improvements in significant figures. Then there was the discussion of how much does Santa Claus weigh

But, like I say, mostly it’s tips on how to get the most from your web browser, improve security, and boost your blog’s performance. It acts as my personal lab book for all kinds of hacks, so I always have an online reminder of tweaks in case I lose track of how I fixed a particular problem. To follow are some of the most commonly accessed pages on the site, hopefully one or two of them will strike a chords and be of use to Sciencebase readers:

So, there you go, if you plan to use any of these, please backup any important data files first to avoid the need for data recovery and don’t blame me if it all goes horribly wrong, you use them at your own risk. I would be interested to hear how you get on if you do apply any of my hacks.

Composting Chitosan Cat-litter Composite

Spectroscopy Now

That has to be the oddest blog headline I’ve come up with this week, but it’s not in fact that esoteric once you get down to it. Basically, researchers in China have created a new material based on dolomite (porous kitty litter material) and the crab shell derivative chitosan.

The new composite material not only absorbs water it can release an NPK (nitrogen, phosphorus, potassium) fertiliser over a prolonged period for use in agriculture and horticulture. Advantages are, improved irrigation efficiency and less run off into waterways together with improved crop yields. More on this, in my SpectroscopyNOW column this week and you get a chance to see a photo of my kitty too. What more could you want? Other than links to the rest of this week’s news in SpecNOW, of course.

In NMR news, a brainy approach to using microNMR coils could allow scientists to probe the activity of cerebral compounds, such as choline, without having to worry about NMR’s relatively low sensitivity. In the X-ray ezine, I report on how British scientists have demonstrated that it is possible to predict the crystal structures of small organic molecules using software, winning them accolades at this year’s Blind Test in Crystal Structure Prediction, organised by the University of Cambridge and hosted by the Cambridge Crystallographic Data Centre.

Finally, new informatics evidence suggests that the land-bridge which is currently the Bering Strait was the sole route into the Americas for humans tens of thousands of years.

Male Semen is Redundant

Male sperm

You’ve seen the kind of thing: “Warehouse Razed to the Ground in Fire”, as if razing didn’t already mean the building was levelled. Worse, “Balloon Ascends Up into the Air”, ascending down is very difficult, simultaneously, at the same time, if not impossible; so too is descending up.

However, the award for the most redundantly tautological headline of the year has to go to Scientific American for Male Semen Makes HIV More Potent, that’s male semen as opposed to the female variety, is it? It’s an important discovery, nevertheless that a chemical constituent of semen affects the immune system facilitating viral infection.

Scientific American is probably not the first and original nor the ultimate and last publication to use this phrase though. DoctorNDTV ran a story with the title: Male semen loss concerns and risky sexual behaviour. Then there’s a research paper in the Journal of Avian Biology that discusses bacteria found in the “male semen” of red-winged blackbirds. Even the venerable and well-respected New Scientist recently published an item on insect courtship and egg laying. Apparently, the trigger for egg laying “is a small protein called sex peptide (SP) in the male’s semen.” Again, the word male, while perhaps making the sentence smoother, is totally redundant and not needed.

A search for the phrase “male semen” on PubMed produced not hits, although “male sperm” came up several times in various journals. So as not to appear sexist, I also did the equivalent searches for “female semen” and “female sperm” and quite surprisingly got several PubMed hits. One paper on mythology mentions how at one time in human history a godly being or other supernatural entity was thought to intervene in the merging of male and female semen to bring about conception. Not quite a modern biomedical reference point, then. The phrase “female sperm” gave absolutely no hits, unsurprisingly.

Maybe the clue as to why these various publications qualify the word semen lies in those papers discussing the mythology of reproduction. A quick Google shows that there are many references to religious and proto-religious texts that discuss both male and female semen as if they were both real. Perhaps by qualifying semen as male in modern writing, rather than simply discussing semen, there is some referential nod to humanity’s misconstrued understanding of reproduction. But, modern understanding of reproductive biology defines semen as a product of the male reproductive organs that acts as a transport medium for sperm, so, like I said, it’s redundant.

I asked linguistic guru Steven Pinker of Harvard University, whose book The Stuff of Thought I reviewed on Sciencebase recently, about this apparent paradox. Pinker told me that he suspects that, “the cause is not a nod to the ancients, but a desire to call the reader’s attention to the fact that it’s
the naturally occurring fluid that encourages the potency of the virus, not some externally administered product.

“Semen Makes HIV More Potent implies to me,” he said, “that adding semen increases the potency, rather than that the HIV exploits the properties of the semen it finds itself in.” He adds that it is peculiar that this may be the case. “Odd that the redundancy should do that,” he told me, “but somehow I think it does.”

Intriguingly, after I contacted Pinker, I saw that the journal Nature, as opposed to the popular science magazine, Scientific American, had covered the same story. In Nature, however, their piece was entitled – Semen boosts HIV transmission. So, for some reason they felt semen does not need a masculine qualification of any kind. The tautology of the phrase “male semen” may seem trivial, but it is an important issue.

David Bradley Abbreviated

I wrote a rather vainglorious post on my Significant Figures site last week – entitled David Bradley: Killer, Lover, Player Puller, it was basically an excuse to do a bit of personal branding but also highlighted the fact that there are so many other David Bradleys out there, including dozens of professors, photographers, a porn star, actors and tractors, and worst of all at least one lawyer.

One of my virtual friends on StumbleUpon, spostareduro, picked up on this article saying it was a great idea for branding. In an email chat though she asked “Do you know how nifty it is to have initials that stand for Data Base.” Obviously, I was aware of this…it was part of the underlying psychology of morphing Elemental Discoveries into Sciencebase when I registered this website’s domain in 1999. However, it got me thinking about what else my initials (I’ve no middle name so, they’re plain old DB) stood for, so here’s a brief list.

  • Data Base – as already mentioned, a database is usually thought of as a structured file containing information accessible with a computer, whether or not I or Sciencebase fit into that definition I couldn’t possibly say.
  • dB – decibels – a useful logarithmic unit for power in acoustics, physics, and electronics. An increase of 10 dB represents a ten times increase in power. Normal conversation bubbles along at 60 dB for instance, a rock concert, at 120 dB, is 1,000,000,000,000,000,000 times louder, which might just explain why so many aging rock stars suffer hearing loss.
  • db (pronounced dee-bee) – is, according to the Urban Dictionary, the ultimate power word, used for expressing absolutely any emotion at all. Of course, in its inimitable style, the Urban Dictionary also has a whole slew of more offensive definitions, which I am not citing here as a matter of principle.
  • In chemistry, my native tongue, DB is both 4-(2,4-dichlorophenoxy)butanoic acid di-n-butyramide.
  • Classiest automotive abbreviation has to be Daimler Benz, unless you add a digit and mention the Aston Martin DB9, obviously, maybe when Sciencebase has a few more dB income I could start saving for one.
  • Sticking with the classy Germans, there is also Deutsche Bahn, the German railway company.
  • And by sheer coincidence, or maybe not the next DB is also German – www.db.com – Deutsche Bank, obviously.
  • Db – dubnium, very heavy element.
  • If you really want more DB’s than you could shake a stick at…check out the wiki entry for DB

UPDATE: Been messing around with name again and have created a page called David Bradley Actor just for fun.

Some time after this, I created a logo based around dB/ figuratively a decibel meter dial.

Cholesterol Hearing Test

Cholesterol Structure

Levels of cholesterol in the membranes of hair cells in the inner ear can affect your hearing according to an article in the Journal of Biological Chemistry. There are two types of sensory hair cells in the inner ear called the inner and outer hair cells. It is the outer hair cells that are affected by cholesterol levels and produce the inaudible sounds in the ear canal.

SOURCE: Baylor College of Medicine

Could Warm Feet Save the World?

Warm feet - photo by spiralz

Wind turbines, photovoltaic power cells, wave energy, porous hydrogen storage composites for fuel cells, carbon sequestration, nuclear, even the idea of damming the Red Sea for a massive hydroelectric power plant are among the high-tech approaches being developed in the battle to reduce our collective size 9 carbon footprints to mere tiptoes.

Saving energy and reducing emissions does not have to be about high tech and macro engineering. The developed world is unlikely ever to give up its dependence on personal motor transport, frequent and pointless air travel, patio heaters, high-definition DVDs, hot and cold running water, and countless other energy-intensive luxuries unless someone actually physical pulls the power plug.

However, for millions of people in the developing world, who may not even be aware of the problems we face with iPhone tariffs, double booked business flights, and lost Facebook friends, life is hard at a much more fundamental level. Aside from poverty, unreliable water supply, malnutrition and disease, even very basic needs are not met, such as keeping warm and dry in freezing mountain villages with no access to heated spa pools and acrylic nail extensions, and wireless internet access to refresh the contents of your Kindle.

D. Buddhi of the Thermal Energy Storage Laboratory at Devi Ahilya University in Indore, India, Atul Sharma of the Department of Mechanical Engineering at Kun Shan University, Tainan, Taiwan, ROC, and S.D. Sharma of UAE Innovations Center in Ras Al Khaimah, UAE have turned to a perennial problem of those without the comforts of central heating and doubly glazed windows – keeping one’s feet warm.

The researchers have designed and tested three foot warmers that can store up solar energy during sunshine hours and then be used during cold evenings as a sustainable alternative to electric heaters. The optimum temperature, the team found in their trials, was just above body temperature. With this in mind, commercial grade lauric acid (which has a melting point 42.2 Celsius and a latent heat of fusion of 181 kilojoules per kilogram was used as the latent heat storage material in their PCM (phase change material) designs. Basically, the material inside melts in the sun and then once the sun goes down the material begins to solidify giving off enough latent heat as it does so to raise the temperature of the container to about 40 Celsius.

They carried out experiments (details are reported in the International Journal of Global Energy Issues) during a winter season to study how well the PCM units performed in the sunny but cold winter climate of northern India. The devices could easily reduce reliance on costly 1 kilowatt electric heaters for keeping the legs and feet warm; and although PCM units do not have the benefit of creating circulating warm air in a room, much of that energy is wasted anyway.

So, could a solar-powered foot warmer save the planet? Perhaps not, at least not until those in the developed world abandon their predilection for vehicle climate control and optical mice. However, alongside other simplified technologies such as solar cookers, arsenic-removing water filters, and clockwork radios, they could at least make a significant difference to the cost of living of people in the poorer parts of the world without compromising their quality of life. Moreover, those in frozen climes will at least be able to keep their feet warm while pondering shag pile carpets and remote control storm shutters.

WiChempedia Coming Soon

It seems it’s now public knowledge that WiChempedia is on its way thanks to Tony Williams at ChemSpider and his colleagues.

“Over the past few weeks I have had a few discussions with a member of the ChemSpider Advisory group regarding a concept to create WiChempedia. I’ve enjoyed these conversations with Alex Tropsha (professor and Chair in the Division of Medicinal Chemistry and Natural Products in the School of Pharmacy, UNC-Chapel Hill),” says Williams in his latest blog post.

Over the past few weeks Williams and his colleagues have been looking at the quality of data on Wikipedia and trying to figure out the best way to mash ChemSpider’s efforts with those of the WP:CHEM team. “Our intention is to deliver wiki-capabilities in ChemSpider and to use the Open Content associated with chemicals and drugs on Wikipedia inside the system,” Williams says, without, he adds, reinventing the wheel or offending the Wikipedians.

“My intention as we work through downloading the data and to check, validate and correct what is sitting on Wikipedia directly for benefit to the community,” adds Williams.

Volcanoes, Moons, Pearls, and Alchemy

Moon (Photo by David Bradley)

This month’s physical sciences Spotlight over on the Intute site turns on oceanic plans, lunar volcanoes, and pearl necklaces:

Infertile Global Warming Plan – Plans to fertilize the oceans with iron or other nutrients in order to absorb atmospheric carbon dioxide and so ward off global warming are not viable according to a report from researchers at Stanford and Oregon State Universities.

Buckyball Pearl Necklace – A new type of polymer material made by stringing together the tiny football-shaped fullerene molecules has been synthesised by chemists in Spain. Under the microscope, the material resembles a string of pearls.

Volcanoes of the Moon – Even though astronauts have set foot on the Moon, analysed its surface and brought samples back to Earth, we do not yet fully understand the Moon’s origins nor how it has evolved during the last few billion years since its formation. New clues have now emerged from a study of the Moon’s past volcanic activity that suggest that volcanic activity began 4.35 billion years ago (+/- 0.15billion), a relatively short time after the formation of our planet’s biggest satellite.

And, in ChemWeb’s The Alchemist newsletter: Small-scale chemistry with a variety of applications that could improve not only healthcare but the environment has led to the Small Times innovation award going to Louisiana Tech’s Yuri Lvov, The Alchemist hears this week. Also in chemistry news, old anticancer drugs could be repurposed for treating genetic blood disorders sickle-cell anemia and beta-thalassemia.

A barrel of fun is to be had analyzing wine barrels for dioxins and polyaromatic hydrocarbons, while laser light has been found to switch vanadia films from reflective to transparent without heating, a possible boon for optoelectronics applications. Finally, in this week’s Alchemical selection, holy double-helical nanorings of DNA with single-stranded gaps have been engineered by German scientists while US researchers have demonstrated that pouring millions of dollars and tons of iron into the oceans may not have the desired effect on reducing atmospheric carbon dioxide levels after all.