Branching out into optics

Dendrimeric molecules are multiply branched compounds that chemists have investigated keenly for their potential applications in medical diagnostics, molecular recognition, catalysis, and photoactive device engineering. Now Mark Humphrey of the Australian National University in Canberra and colleagues have developed organometallic versions of these compounds that are more stable than others. They investigated alkynylmetal complexes because of their potential to form materials with non-linear optical characteristics. Novel NLO materials will be crucial for the generation of opto-electronic computational and communications devices as well as in new types of sensor protection from laser threats.

Read on…

Crystallising thoughts on bird flu

UK researchers have determined the X-ray structure of a key protein of the avian influenza virus that reveals a peculiarity that might prove the Achilles’ heel of bird flu and allow new potent drugs against the disease that could stave off a flu pandemic.

H5N1 virus is named for the particular haemagglutinin (H) and neuraminidase (N) proteins that are found on the viral coat. Haemagglutinin allows the viral particles to bind to and infect host cells, while neuraminidase helps the virus to escape infected cells and attack new ones. There are 16 H’s and 9 N’s in known variants on the influenza type A virus.

It is the neuraminidases that are the target for drugs such as oseltamivir (Tamiflu) and zanamivir (Relenza). The trouble is, N1 is not the exact target for which they were designed. Rather the design of these drugs was based on neuraminidases N2 and N9 found in other influenza type A strains. H5N1 itself resides in a genetically distinct group. Structural information from this group could be critical to producing drugs that are resistant to emerging resistance in influenza.

Read the full story in my latest news round up at spectroscopynow.com

Nervous analysis

Chemical communication between nerve cells underlies brain functions, such as the control of sensory and motor processing, memory and learning. Monitoring neurotransmitter secretion is crucial to studying and understanding how the brain works. Various research teams have endeavoured to develop techniques for monitoring neurotransmitter release at the single-cell level, according to researchers in The Netherlands only invasive methods such as electrophysiological techniques and fluorescent probe labelling have provided adequate temporal and spatial sensitivity. These limits suffer from being limited to specific analytes.

Now, the researchers have turned to a specialist spectroscopic technique to develop a new approach to monitoring neurotransmitters that is non-invasive and side-steps the issue of analyte limitations.

Read the complete story in SpectroscopyNOW.com

High performance spectroscopy

High performance liquid chromatography (HPLC) is usually the technique of choice for separating and analysing complex mixtures of small molecules in laboratories around the globe. As such, a whole range of specialist materials for particular types of analyte have been developed. French researchers, however, have now developed a novel approach to separation and analysis based on NMR that uses a simple solid support, such as porous silica gels.

Guilhem Pagès, Corinne Delaurent, and Stefano Caldarelli of the University of Provence and Paul Cézanne in Marseille, France, recently developed an alternative for identifying components in a mixture that avoids the complexities of chromatography and relies instead on solid-enhanced diffusion-based NMR.

“The determination of the components of assemblies of small molecules is an extremely common task in chemical labs,” the researchers say. A method that mimics part of the chromatography process can they explain achieve good separation for certain types of common mixture but using only very simple chromatographic materials, which not only simplifies the analytical process but is far less expensive than employing sophisticated materials.

More…

Photochemistry without light

photochemistry without light

Infrared and nuclear magnetic resonance spectroscopy are anything but child’s play, but now US chemists have used these techniques to follow the chemistry of “light sticks” and to develop a light-free version of photochemistry. This contradiction in terms could be exploited in a remote cure process for photopolymers, they say, allowing inaccessible cracks in pipes, joints or containers, to be sealed as well as having other practical applications in coatings, paints, varnishes, adhesives and sealants.

Light sticks hold children’s parties in awe with their eerie yellow-green glow as well as providing emergency lighting without electricity or a naked flame. The chemistry taking place when the stick is “snapped” and the materials mix involves oxalyl chloride and hydrogen peroxide reacting in the presence of a fluorophore, which emits light as the reaction proceeds.

Read the full story in the latest news round up from David Bradley on SpectroscopyNOW.com

Ask Jeeves about science

Here’s a top listing of questions that bring readers to sciencebase from the Ask Jeeves search engine. We cannot promise to answer them all here, but search the site and you may find enlightenment or at the very least some factlets of even more interest.

How old was Einstein when he wrote his papers on relativity?
When were the largest glaciers in history?
Where can I find some wow facts about sodium?
When Mars will look as large as the full Moon to the naked eye?
How much does the Japanese government spend on computers?
What planet is most like Earth?
How many barrels of oil do Americans use every day?
What is the width of a dime?
Why can’t frogs smoke?
How far is Sedna from the sun?
How do humans recognize faces?
What killed Otzi the iceman?
Where is the Earth’s crust thickest?

Resurrecting Pluto

As Sciencebase reported recently, a session of the International Astronomical Union (IAU), meeting in Prague, during August passed a resolution re-defining the nature of the planets of our solar system. Apparently, only about 428 of the IAU’s almost 10000 membership was involved in the voting. The original proposal would have led to an expansion of our solar system from the familiar nine planets to 12, for now. But, as we now know things turned out very differently.

This proposal was modified at the conference, with the aim being to exclude from the definition of planet all but the eight largest planets, which meant Pluton was dwarved. The vote leaned towards this definition, much to the chagrin of the wider IAU community, which believes neither definition was subject to critical review by the broader planetary
science community prior to the conference, despite simple means to do so.

A grass roots petition stating: “We, as planetary scientists and astronomers, do not agree with the IAU’s
definition of a planet, nor will we use it. A better definition is needed” has now emerged – http://www.ipetitions.com/petition/planetprotest

According to a press release from the Planetary Science Institute, in less than five days more than 300
professional planetary scientists and astronomers had signed the petition. “The list of signatories includes researchers who have studied every kind of planet in the solar system, as well as asteroids, comets, the Kuiper Belt, and planet interactions with space environment. They have been involved in the robotic exploration of the solar system from some of the earliest missions to Cassini/Huygens, the missions to Mars, ongoing missions to the innermost and outermost reaches of our solar system, and are leading missions preparing to be launched,” says the release.

The list also includes prominent experts in the field of planet formation and evolution, planetary atmospheres,
planetary surfaces and interiors, and includes international prize-winning researchers.

“This petition gives substantial weight to argument that the IAU definition of planet does not meet fundamental scientific standards and should be set aside,” states petition organizer Dr. Mark Sykes, Director of the Planetary Science Institute in Tucson, Arizona. “A more open process, involving a broader cross section of the community engaged in
planetary studies of our own solar system and others should be undertaken.”

So, as we predicted, Pluto’s status could be changed yet again. Meanwhile the guy on the Clapham omnibus will probably stick with the idea that Pluto is a planet regardless of the outcome of this debate.

Premature diagnostics

An MRI scan can help in predicting future developmental outcomes of pre-term infants, according to US researchers. The scan reveals abnormalities no picked up by cranial ultrasound and can be used to predict problems that would become apparent by age two years.

Terrie Inder of Washington University School of Medicine in St Louis working with colleagues in New Zealand and Australia have discovered that MRI can reveal brain abnormalities in very premature babies born at 30 weeks or less. They monitored 167 pre-term infants from birth to age two years having graded these abnormalities to see if there is a correlation with any severe delays in cognitive and psychomotor development, cerebral palsy, or hearing or visual impairments in the two-year olds.

Read on…

Chitika

No doubt I’ll get round to creating a Chitika stream for my readers viewing pleasure. But, first, just check out the blurb with which they try to entice bloggers:

“Chitika eMiniMalls bring life to product promotion on the web. With eMiniMalls you can hand-select specific products (or product categories) targeted to the content of your webpage, and provides your users with robust comparative shopping information to make an informed buying decision – before they leave your site. As users click, you make money.”

Unfortunately for a science blog and its readership, they don’t yet have a minimall for silica gel TLC plates and test-tubes, maybe one day.

Periodic Post

Periodic table of sex

Mosts chemists get to see some wacky periodic tables during their careers – circular ones, spiral ones, ones that rearrange all the elements etc etc. Then there are the foody ones and then there are the giant periodic tables, the arty farty ones, the online version, the flash table.

And, then there’s the periodic table of sex.

I didn’t think it was real at first, but several sciencebase visitors have been searching for this incredible object during the last few days, so I thought I’d uncover the truth. Apparently, just such a PT exists, its elementary in the most lewd way, but is available from Amazon. Apparently, allposters.com have stopped selling it, so I’d grab one while you can: Periodic table of sex

It’s not every post I get to categorise as chemistry, sex and geek all at the same time, but this one was simply begging for it. I hate to think what good-ole Dmitri Mendeleev would have made of it though, but surely it’d make the perfect gift for the chemistry student in your life. Wouldn’t it?