Author: David Bradley

Predicting Chemo Success

French researchers have identified almost 700 genes in the tumours of colorectal cancer patients
whose expression was different between patients who subsequently responded well to combined chemotherapy and patients who were resistant to the therapy. The findings could ultimately help cancer specialists decide which course of treatment for patients with colorectal cancer is most likely to work best.

Sandrine Imbeaud from the CNRS and Pierre and Marie Curie University, Villejuif, France, used microarrays to analyse the gene-expression patterns of samples from colon tumours and liver metastases collected from 13 patients with colorectal cancer. The microarray analyses were carried out before the patients were treated with combined chemotherapy of folinic acid,
5-fluorouracil and irinotecan. The team identified 679 genes that were produced differently in patients who later responded well to chemotherapy.

Details of the research were published today in the journal Genome Biology.

Alchemy Infamy

ChemWeb’s Alchemist gets cracking with an alternative approach to gasoline production from The Netherlands, finds out how to protect fashion-conscious athletes from impact injuries, checks out the soft core particle scene, and discovers a possible mechanism for how diabetes drugs work. Also in this weeks musings, we hear that French researchers have carried out the first experiments to measure how heat flow behaves far from a heated surface, which could help us understand not only something as mundane as the interior of a star but also air conditioning units!

Science & Engineering Encyclopedia

Charlie Hawkins emailed to tell us about a new science & engineering encyclopedia called DiracDelta*. It is completely free to use, as one would hope, given the existence of Wikipedia, and they update their database on a daily basis. A new version appears monthly, which is more than you can say about good-old paper encyclopedia’s of course. Currently, there are about 5000 pages, some of which have more detail than others, but Hawkins emphasises that this is a work in progress and always will be.

One of the most interesting aspects of DD is not the encyclopedic entries themselves, but the various applets including a clipboard and calculator that allow readers to work more interactively with the data presented. Moreover, there is a whole stack of scientific tools that allow you to input values directly and work out everything from aerodynamic drag coefficients to signal processing bandwidths by way of decibels, fuel consumption, and moments of inertia.

*No relation to AlphaGalileo as far as I know!

SciScoop Science Blog

UPDATE: April 2009. After four years running SciScoop under the same voting and hosting system as the previous webmaster, I thought it was time for a change! We reached well over 4000 signed up members and 3000+ individual posts almost all with a least a couple of comments and a massive RSS feed subscriber base. Anyway, I’ve now relocated the site to a new WordPress-type host, overhauled the theme and site entirely with help from my good friend Ariel. We are now hoping to gain new supporters as well as new contributors. Do get in touch if you’d like to write a guest blog post on SciScoop!

We’re coming up to the first anniversary of David Bradley taking the helm at SciScoop and what a rollercoaster it’s been, site traffic rocketed early on (to mix a metaphor or two) and the settled down again, only to spike once more in October 2005. We’re seeing a steady 5000 readers a day now…and are way past the 2000-story point (all searchable of course). SciScoop is still riding high in Google News for lots of the latest cutting-edge science news as well as some of the more offbeat theories.

Now is the time to show your allegiance, forget those other science forums, and get along to SciScoop where you can post news items, comment and vote on other people’s submissions, and ultimately see your name bathed in the glorious SciScoop light, or at least framed with a nice shade of blue.

We’ve already got some excellent regular writers, but could always do with more contributors. If you’re a science student looking to get into science communication, for instance, or majoring in media or journalism and have an interest in science, then SciScoop could offer you your first published byline and a chance to beef up your resume.

Visit the SciScoop Science Blog and sign up for membership, check out our science news sources and add your own spin to the latest discoveries in science! SciScoop covers everything from astronomy to zoology and all that’s in between.

Hope to see you there soon!

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Divine Trigonometry

Picture math class without those confusing sines, cosines, and tangents. Picture an architect working out the surface area of various building structures without having to work through a range of degrees. In short, how much simpler trigonometry would be if we could remove the complicated bits and distil it down to crystal clear calculations.

University of New South Wales mathematician Norman Wildberger has done just that and espouses the theory that a rational, algebraic approach to trigonometry could open the way to a universal geometry. His is a revolutionary text, essentially overwriting centuries of tedium with a crisp new approach that is bound to raise hackles among conventionalists. However, Wildberger is not discarding the foundations of mathematics, instead he is constructing an architecturally sound new geometry that unites number theory and algebra and simplifies many geometrical problems.

In “Divine Proportions”, Wildberger (an alumnus of Toronto and Yale) clearly lays out the required definitions and theorems and illustrates tehm with useful formulae, diagrams and exercises.

If you’re a professional mathematicia, scientist, engineer, or a student who wants a different take on their studies, this book could change your understanding of mathematics.

Killer Coral Compound

Jerry Pelletier of McGill University, in Quebec, Canada, and colleagues have discovered a small molecule (which means it could be easy to make) in coral that can inhibit the replication of certain viruses. The research shows that the natural product, known as hippuristanol, blocks the protein-production machinery in cells that is hijacked by viruses and so halts a viral invasion in its tracks.

Hippuristanol is produced by the coral Isis hippuris, hence the compound’s name and seemingly prevents the viral protein, eIF4A, from binding to messenger RNA, mRNA. mRNA carries the code to make proteins from DNA to specific sites of protein synthesis in the cell. By binding to the mRNA, eIF4A initiates the translation of the protein code. Hippuristanol prevents replication by inhibiting this process.

Viruses, such as poliovirus hijack this protein machinery and so can be blocked by hippuristanol, at least that’s the theory. Hippuristanol could soon join the growing arsenal of antiviral compounds although it is still a long way off from being added to the GPs prescription books.

You can find the complete paper in Nature Chemical Biology: http://dx.doi.org/10.1038/nchembio776

Herbal Hogwash

Why is it that in a centre of scientific and medical excellence, namely Cambridge, do the city’s powers that be think it’s a good idea to let a herbalist pedal their wares in a prominent city centre shop?

At best, the products on sale are pseudoscientific hogwash for which any positive effects are likely to be mere placebo in origin. At worst, the apothecary’s shelves are laden with unregulated, untested, and potentially toxic materials that dupe those with any of a vast range of diseases into believing in a panacea for their ills that simply does not exist.

If these products worked, wouldn’t it be an obvious sector of the market for the pharma industry to move into? Surely, that would have happened already, if these products worked…

Natural Chemicals

Here’s a thought “natural” is not all good and we really couldn’t live our lives as we do without “synthetic” chemicals. It’s a theme that is rarely acknowledged by the mainstream media, but a UK organisation known as “Sense about Science” is hoping to persuade British journalists, at least, of the truth of the matter. Earlier this year SaS published a neat little booklet, aimed primarily at writers and editors on so-called lifestyle magazines, that highlights the top misconceptions about chemicals. You can now download the booklet pdf here.

In it, the organisation corrects six notions, affirming that you cannot lead a “chemical-free” life, synthetic chemicals are not inherently dangerous, synthetic chemicals are not the main cause of cancer and disease, exposure to chemicals is not a ticking time-bomb, it is not always beneficial to avoid synthetic chemicals, and we are not subjects of an unregulated, uncontrolled experiment.

Visit the SaS site, or download their booklet for the full skinny.

I spoke to the organisation’s Chris Tyler this week and he explains how combating chemophobia involves constantly repeating the message that the lifestyle media has been so keen to disparage. It seems, however, that the organisation and their booklet is having some success. “We seem to be making some headway with the lifestyle sector,” Tyler told me, “comments like ‘but we all
know that detox socks don’t really work’ and ‘of course not all synthetic chemicals are bad’ are appearing more often, in the magazines.” So, maybe the tide is turning, perhaps the message really is getting through…

Trackback this posting to help spread the word beyond the shores of fair Blighty.

Lazarus Rats

Mammalian paleobiologists must be a cynical lot. How else to explain their presumably ironic use of the term Lazarus Effect in piecing together the very evidence for evolution that must by its nature preclude much of what is discussed in the same context as Lazarus? Moreover, this particular piece of evidence is one that plugs a gap in the fossil record and helps bring continuity to the theory of evolution, something that is often considered a fatal flaw by those who’d dispossess it. You could say they’ve brought it back to life…

Anyway, a new type of rodent discovered last year in Laos is a survivor of a group believed to
have been extinct for 11 million years, according to a new study published today in Science. Mary Dawson and colleagues compared skeletal remains of the squirrel-like animal with those of a little understood extinct group of Southeast Asian rodents and confirmed that it is actually a living member of this long-gone family. When the new species was discovered in early 2005, it drew wide acclaim because it was thought to be a member of an entirely new family of living mammals. Instead, according to the researchers, the rodent represents a striking example of the ‘Lazarus effect’ in which an organism suddenly reappears after a long gap in its fossil record. That such a phenomenon has only rarely been documented among mammals and other vertebrates shows that Southeast Asia’s prehistoric ‘zoo’ can offer invaluable insights regarding past and present
biodiversity, the researchers write.

Bursting the Fusion Bubble

Fresh questions surrounding Rusi Taleyarkhan’s work on bubble fusion, are raised today in an exclusive news report online in the journal Nature.

Purdue University nuclear engineer Taleyarkhan, came to prominence in
2002 when he claimed to have achieved table-top nuclear fusion in collapsing bubbles. If the effect were real, and could be harnessed, it could provide us with effectively unlimited energy at very little cost.

However, several of Taleyarkhan’s colleagues at Purdue have revealed to the journal that their confidence in his work and results has been seriously dented since he arrived in their department in 2004. Faculty members Lefteri Tsoukalas and Tatjana Jevremovic, along with several others who do not wish to be named, say that since Taleyarkhan began working at Purdue, he has removed the equipment with which they were trying to replicate his work, claimed as ‘positive’, experimental runs for which they never saw the raw data, and opposed the publication of their own negative results.

Moreover, UCLA’s Brian Naranjo is submitting a paper to Physical Review Letters that provides an analysis of Taleyarkhan’s recently published data. The conclusions strongly suggests that Taleyarkhan did not detect fusion, but a standard lab source of radioactivity. This latest episode seems certain to burst the bubble, but Nature leaves a caveat in their press release on this subject:

“Bubble fusion is theoretically possible,” the journal says, “but do these latest findings spell the end for this particular line of enquiry?”

Well, perhaps it isn’t their place to actual wield the needle, but on the basis of Naranjo’s study it certainly looks like the bubble has gone pear-shaped to say the least.