Climate Change Contradictions

We all have so-called climate change targets to meet. So, you’d think we would be doing everything we can to cut carbon emissions, conserve energy etc.

It sometimes looks like we’re heading in the “right” direction – wind farms are sprouting up all over the place and forests are being harvested for biomass fuel rather than our digging away at ancient fossil hydrocarbons…but it doesn’t really add up really does it?

How much energy does it take to build one of those turbines and how long do they last? Ditto plant and managing supposedly “sustainable” forests for biomass?

Couple that announcements about new airports and runways that will multiply passenger capacity and one has to wonder…

The BBC today reports that Prince Charless sees climate change as the “greatest challenge to face man”…he’s such an expert, of course. Oh, and he’s worried about bird flu.

How safe are safe insecticides?

Researchers have detected high concentrations of the popular insecticide class known as pyrethroids in suburban stream sediments, raising concerns about its effects on aquatic life. Pyrethroids are the common active ingredient in most domestic insecticides and have been marketed for many years as a more environmentally benign alternative. However, little information has been gathered until now about their effects on wildlife. A study published in Environmental Science & Technology could help clarify their status.

Search PubChem for Molecular Structures

Steve Heller just posted an update on on the PubChem system to the CHMINF-L discussion group.

PubChem now has additional bioassay and related information and the number of depositing/cooperating organizations now numbers 25, he told the group.

With 5,269,228 unique substances listed, now is a good time to track down that elusive molecular structure you’ve been searching for. ChemSpy.com offers quick and easy access to the PubChem search system

Tamiflu Molecular Structure

molecular structure of TamifluRoche is allegedly struggling to keep up with unprecedented demand for its antiviral Tamiflu in light of the massive media scaremongering that is going on globally thanks to the emergence of the H5N1 strain of bird flu. Taiwan already intends to stockpile a generic version of the drug oseltamivir with or without Roche’s permission. Currently, oseltamivir is synthesised from shikimic acid, which is obtained from the star anise fruit. The total synthesis takes at least ten steps, but chemists are working on simpler approaches.

That aside, Nature just reported a case of a girl with a strain of H5N1 that is resistant to this drug. If prevalence is high, then the media will have even more scare-mongering to do.

Flu Resistance

The international science journal Nature has lifted the media embargo on an important paper due for publication next week – The paper raises the possibility that the current prophylactic regimen for Tamiflu (oseltamivir) may have contributed to the emergence of partial resistance to the drug in a Vietnamese patient.

This paper provides an analysis of an H5N1 virus — isolated from a
patient in Vietnam earlier this year (1) – that is partially resistant to
oseltamivir.

The potential emergence of a resistant virus is a continuing concern of
health agencies, although evidence to date suggests that viruses with
mutations giving rise to resistance have reduced fitness, making them less
transmissible and of lower pathogenicity.

The paper highlights the fact that the current recommended
prophylactic treatment regimen may involve suboptimal doses and
durations of oseltamivir treatment that could contribute to the emergence
of resistant virus. It also raises the possibility that a larger arsenal
of influenza antivirals may need to be developed. Stockpiling zanamivir
(sold as Relenza) in addition to oseltamivir may be warranted.

Although the case described in this paper was part of a family cluster,
the paper does not directly address the issue of human-to-human
transmission of H5N1.

Nobel Prize for Literature 2005

Is it any surprise there is a gulf between science and arts?

This is what the art world seemingly considers important: Harold Pinter "in his plays uncovers the precipice under everyday prattle and forces entry into oppression’s closed rooms"

Whereas science renders discoveries in chemistry that offer “Fantastic opportunities have been created for producing many new molecules – pharmaceuticals, for example. Imagination will soon be the only limit to what molecules can be built!”

Earthquake Refusal

It’s the news that should set the press a tremble, but fellow science journalist Natasha Loder has had to resort to posting an item about the refusal of Pakistan to grant leading Himalayan earthquake expert Roger Bilham an entry visa on her blog. At a time when one would expect intellectual activity in this field to be desperately needed, apparently scientists are not allowed into the country because this is not a time for “intellectual activities”, reports Loder.

Bilham and his colleagues at the University of Colorado have been forewarning of a major Himalayan earthquake for years, but the Kashmir earthquake released only a tenth of the potential energy stored in the region and Bilham further expects geological unrest.

His expertise could provide critical clues to when and where that pent up energy might be released…surely such intellectual activity is not just desirable but essential.

Research into magnetic materials and frustrated magnets

Some time ago I wrote a feature article for EPSRC Newsline about frustrated magnets, the article is available on sciencebase.com and has attracted the attention of a fair few web surfers. Interestingly, the most recent of them hit the page in question while searching for “picture of a frustrated parent”. Odd, I thought. So, I did the search myself on the SE they’d used and found that very page at #3 in the search engine results page (SERP)!

Now, I know websurfing can be a frantic occupation, but surely the text that was displayed in the SERP didn’t point to any photographic evidence of parental frustration…

“The conventional picture of a magnet says each atom in a material … Harrison. In such a ‘frustrated’ lattice, the conventional forces … Harrison spotted the parent compound, potassium hydroxy …”

Whatever. I hope the surfer in question found their picture in the end. I could provide one of a frustrated webmaster easily…

Toxic Aftermath

The floodwaters that engulfed New Orleans after Katrina turned out to be less toxic than scientists predicted. But, the same floodwaters pumped back into Lake Pontchartrain nevertheless carried with them high levels of various metals, including copper and zinc. Researchers at Louisiana State University writing in the October 11 issue of ES&T suggest this might pose a long-term risk to the area’s aquatic life.

Genetic Google

Google is fast, you have to agree…it can somehow narrow down a search of billions of webpages and bring you a list of the “most relevant” within fractions of a second. Admittedly, sometimes that list can be long, but it’s still quite astounding how it does it. Anyway, it occurred to me that maybe its indexing method and algorithm might be useful to those who search DNA databases.

Chemists are slowly beginning to recognise how Google can be used to search for unique chemical structures using the INChI format, so maybe there is potential for DNA searching. Maybe DNA searching is already fast enough, but I somehow doubt it.