Author: David Bradley

In chemistry, hydrophobicity (from the combining form of water in Greek hydros and for fear phobos) is the physical property of a molecule that is repelled from water. Hydrophobic molecules tend to be non-polar and thus have a greater affinity for other neutral molecules and non-polar solvents. Hydrophobic molecules in water often cluster together forming tiny bubble-like structures known as micelles.

The opposite of hydrophobic is hydrophilic. A hydrophilic substance, from the Greek hydros for water and philia love, is a molecule or other molecular entity that is attracted to, and tends to be dissolved by, water. A hydrophilic molecule is one that has a tendency to interact with or be dissolved by water and other polar substances including solvents; the interactions are more thermodynamically favourable.

Water always was a slippery character. Now, scientists at Pacific Northwest National Laboratory have made an incredible thin layer of water, just a single molecule thick, that sits on a slab of platinum metal and refuses to freeze. Strictly speaking, the monolayer held at just 60 Kelvin becomes hydrophobic and will not allow ice crystallites to form on its surface.

What’s that you say, “hydrophobic water”?

Denial doesn’t get any more profound than that, even if we are talking about molecules.

According to Physics News Update: “Weaker bonding results in a “classic” hydrophobic state, in which the water merely balls up immediately.” So, it’s a balls up, is it? That explains a lot.

Diethylstilbestrol (DES) is a synthetic nonsteroidal estrogen that was first synthesized in 1938. Human exposure to DES has allegedly occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers.

From 1940 to 1970, DES was actually given to pregnant women in the belief that it would reduce the risk of pregnancy complications and losses. In 1971, DES was shown to cause a rare vaginal tumour in girls and young women who had been exposed to this drug in utero and the US FDA subsequently withdrew DES from use in pregnant women.

Dan Lednicer offered us a guest editorial some time ago that mentioned the ill-fated drug diethyl stilbestrol (DES) and the toxicity of this and other compounds. Here’s the 3D chemical structure of DES for recent visitors to Sciencebase who were looking for it!

Diethylstilbestrol is an orally active non-steroidal estrogen first made in 1938 and originally approved for use in gonorrheal vaginitis, atrophic vaginitis, for menopausal symptoms, and in postpartum lactation suppression to prevent breast engorgement.

However, in 1971 it was found to be a teratogen – causing birth defects – when given to pregnant women and later a carcinogen. It is currently used only in veterinary practice at very low (hypocarcinogenic) doses for treating female canine incontinence.