Genetically Modified Cocaine

Developed nations continue to argue the toss about the safety of genetically modified crops and foods, but meanwhile in remotest Colombia, coca farmers are reported to have produced a GM coca plant.

There is much bluster from the authorities that the plants are nothing but a product of improved fertilisers or a better compost. But, that smacks of denial to me. The plants are almost three metres tall, are resistant to most common weedkillers and apparently produce four times (according to the Financial Times; eight times, says The Independent) as much cocaine as normal plants. If that’s just the result of a trip to the local garden centre for a sack of soil improver, then someone can send me a couple of bags for my tomato plants next spring!

Burning Water

Photo from www.joe-ks.com

Just this minute, I received an email from someone claiming they had discovered how to burn water.

No matter what experimental conditions they set up this is physically impossible – fundamentally standard combustion involves the oxidation of some material into the oxidized form of that material and water. The reaction 2H2 + O2 –> 2H2O puts it at its simplest. Energy is released in this reaction. The reverse process is possible, it can be done by adding a small amount of ionic material to the water to make it a salt solution and passing through it an electric current. That splits the water molecules, releasing hydrogen gas and oxygen in a process known as electrolysis. But, this is not combustion, energy must be fed into the system (electrical in this case) to split the water molecules, the ionic salt particles simply act as carriers of the current.

The notion that somehow you could overcome the bonding between hydrogen and oxygen atoms in H2O might be overcome in a combustible manner rears its ugly head on a frequent basis. But, as you can see it’s just not tenable. If you were stupid enough to connect a car battery’s terminals to a bowl of salt water, you could ignite the resulting hydrogen bubbling from the mixture, but that could be no more describes as “burning water” as baking a cake by mixing and freezing the ingredients in a cake tin.

The idea that burning water might be possible is yet another example of the kind of thinking that repeatedly suggests perpetual motion might be possible, it’s desperate grasping, it’s almost a cry for help: “We have messed up the world, but I can fix it, if you listen to me!!!” That kind of thing!

And, while we’re at it, there’s a College in the UK that offers absolutely no science courses, but does offer dowsing, and advanced dowsing! It’s the Women’s Institute Denman College, apparently.

This post, was originally published in the old Sciencebase blog – SciObs – on December 8, 2004, but I’ve resurrected it and edited it up in the light of events that took place in 2007. You can read about the posts that emerged here:

How not to grab the blogosphere – this one is very closely related to this old post.

Free cure-alls – not just cure-alls for disease but for all the problems that ail the world. Yeah, right!

Telesales Revelations

A British telesales company recently sent off its workers’ computer keyboards for analysis to a nutrition expert to find out exactly what its staff were doing at their desks in terms of eating habits. Unsurprisingly, the analysis of the detritus stuck in and among their keys revealed that most staff were snacking heavily on sandwiches, cakes, pasties and the like while working at their desk. Splashes of tea and coffee were also commonly observed. Fragments of crisps, grains of sugar and nail clippings (toe and finger!) too emerged from within many of the keyboards after a good shake.

But, never mind the snacking and personal grooming. A male pubic hair found stuck under one worker’s "ESC" key has not yet led to a dismissal. The company, however, is planning to move to an open plan office rather than its current cubicle-based layout to reduce the alleged, ahem, "time-wasting" that was presumably underway in at least one workstation prior to the analysis.

Chemical Image Problem

It’s not been a hot week for the image of the chemical industry. This week marked the 20th anniversary of the Bhopal tragedy. There were more revelations about problems with pharmaceuticals. Researchers reported that benzene is worse than we thought even at low levels. And, the industry is denying WHO claims that chemicals harm kids.

Couple that with further discussion about the future, or rather lack of, chemistry teaching at British universities and the supposed benefits of downsizing the number of chemistry departments and one begins to wonder whether there will be any chemical industry to speak of in five years time.

Chemophobia has been high on the agenda perhaps since even before Rachel Carson’s Silent Spring. What is to be done about redressing the balance? Industrial visitors to Sciencebase may wish to get in touch with their ideas…

Scholarly Google

Scholarly Google

Google is just so active these days what with its desktop search tool, the beta of Google Groups 2, and now something specifically for academic-type research – Google Scholar – a scholarly Google in other words. It looks at first glance rather promising, being potentially a replacement or a complement to Elsevier’s Scirus…but, you’ll notice my carefully worded description "academic-type". It seems that a lot of early adopters are already finding the fatal flaws in its results, so if you were looking for a serious web research tool for science this is probably just one to add to the arsenal rather than being the weapon of mass deduction you were after.

Post note: Moreover, although this is a scholarly Google, there are a growing number of scientific tools online now that circumvent the need for such an academic search engine. With the advent of Connotea, ChemRank, and ChemRefer, and other such wonders, finding scholarly information is almost a cinch.

Fat Gamblers Smoking

The UK government is set to introduce new warning labels on fatty and sugary foods (in the style of the warnings found on packets of cigarettes and other tobacco products.) At the same time it announces that smoking in enclosed public places will be banned within four years and then tells us that it has plans to import Vegas-style super-casinos into the country and to open the pubs 24 hours a day!

What’s going on?

They want us to cut down on fattening food, give up smoking, drink more and take up gambling. Could it be that they’re simply worried that duties on rich foods and cigarettes will plummet in the next five years so they’re shifting the emphasis to booze and gambling to compensate? Your thoughts on that subject are most welcome.

Chemistry of Moores Law

Everyone knows a version of Moore’s Law that states: the number of components on a unit area computer chip will double every 12 months. Empirically, it’s turned out to be every 18 months, but it doesn’t just apply to chip density, but highest hard drive capacity at any given time, CPU speeds, and RAM requirements (the computer hardware and software industries form a self-perpetuating ascending double helix in case you hadn’t noticed). The Chemical Heritage Foundation is marking the fortieth anniversary of Intel co-founder Gordon E Moore’s Law in May next year a celebration of the fact that without an equivalent doubling in chemical savvy none of those advances in computing would have been possible.

Spectral Lines at 40

Spectral Lines is just one of three specialist webzines prepared exclusively for the spectroscopyNOW website by David Bradley Science Writer. In Issue 40 of the spectroscopy news magazine he takes a polarized view of the Big Bang, finds out how spectroscopy could help patients avoid getting the needle, how German scientists are testing atmospheres, and discusses a new approach to finding a compound’s crystal structure without x-rays: spectroscopy news

Green silicon production

Making the electronics industry green

Green silicon electronicsA new electrochemical process for silicon extraction could make large-scale production of this widely used material more environment friendly, according to chemists in China.

Silicon has an essential role in the world of electronics, being familiar in countless components from microelectronic silicon chips and optical fibres to large solar panels. It is also employed in the production of silicones, which are used in everything from bathroom sealant to cosmetic augmentation materials. Silicon even finds a role in alloy production.

Industry generally uses a straightforward reduction method to produce elemental silicon starting with silicon dioxide (SiO2 in the form of quartz). Carbon is the reductant and the process is carried out at 1700 Celsius. Carbon dioxide is the by-product as oxygen is released from the silica. According to Nottingham University’s George Chen currently a Specially Invited Professor in the College of Chemistry and Molecular Science at the Wuhan University in China, this process was used to produce about 4.1 million tonnes of silicon world-wide in 2002, with a corresponding release of 6.5 million tonnes of the greenhouse gas carbon dioxide into the atmosphere.

Chen and his colleagues, Xianbo Jin, Pei Gao, Dihua Wang, and Xiaohong Hu, believe that a more environment friendly approach should be attainable using electrochemical reduction rather than the conventional energy-hungry carbothermal process. “The old-fashioned charcoal technology should be replaced by a more advanced process from the environmentalist viewpoint,” the researchers say.

Electrolytic production of silicon was first carried out as long ago as 1854 by French chemist Etienne Henri Sainte-Claire Deville (1818-1881). A purity level of 99.999% has since been claimed by GM Rao and colleagues using fluorosilicates in a molten fluoride. In the early 1980s, however, results began to suggest that silica would be the ideal raw material, but high temperatures would be needed to make these processes work. The Wuhan researchers have now revealed a new electrochemical technique, which they claim will become viable for the large-scale production of silicon, because it avoids the high energy costs and reduces the carbon dioxide emissions considerably.

For the electrochemical extraction of silicon, Chen and his team took the approach of using silicon dioxide itself as the material for the negative electrode (cathode). They also opted to use molten calcium chloride as the best electrolyte for the job. Calcium chloride is well known as an electrolyte for electrochemical reduction of metal oxides at high temperatures. Sharp-eyed readers will have spotted the potential flaw in their arrangement, however. Silicon dioxide is, of course, an electrical insulator. Nevertheless, the researchers persisted with their idea and found in initial tests that conversion of quartz to elemental silicon does in fact occur at the three-phase boundary between the silicon dioxide, the electrolyte, and the flattened end of the tungsten wire that is used to connect the electrode to the circuit. This provides enough impetus for the electrochemistry to kick in properly as the silica is gradually converted to conducting silicon.

Theoretically, says the team, the reaction should eat its way through the entire silica electrode. However, the researchers found that in practice only a small area around the tungsten plate is in fact converted. They explain this in terms of the physical characteristics of the electrolytic melt – it simply cannot penetrate sufficiently deeply into the newly formed silicon layer on the surface of the silica electrode. This has the inhibiting effect of preventing further formation of the three-phase boundary and so the electrochemical reaction grinds to a halt.

Determined to make the process work though, Chen and his co-workers have now found a practical solution. Instead of using a solid quartz electrode, they have switched this for silicon dioxide powder that has been pressed into thin pellets and then sintered. The resulting electrode is, of course, then porous enough to allow the electrolytic melt to penetrate more deeply into the material of the electrode. Indeed, the particles, just a few micrometers across, are much more effectively converted to silicon powder by the electrolysis process than in the solid silica electrode. The use of X-ray diffraction provided the researchers with assurance of the purity of the silicon they were producing.

In terms of industrial application, high purity, low-energy, and reduced carbon dioxide emissions will all be rather desirable properties of the new silicon-production process. Moreover, as bulk quartz would not be practicable for industrial production, the discovery that silica powder, which is far more readily available, works with this degree of success is much more likely to be make the process attractive to silicon manufacturers.

In addition, the researchers discovered that by mixing the quartz powder with other metal-oxide powders it is possible to directly produce fine-tuned alloys using their electrochemical reduction method. Fine powders of oxides can be prepared easily and mixed uniformly, the researchers explain, so that the electroreduction of such mixtures leads to an alloy, the composition of which is precisely controlled. They have successfully produced Si-Fe and Si-Cr alloy powders with a particle size of 2-3 mm in this way.

Despite the long history of silica electrolysis dating back to the mid-nineteenth century, Chen and his colleagues have demonstrated, for the first time, that porous pellets of silica powder or mixtures with other metal oxide powders can be electroreduced to pure silicon or its alloy in molten calcium chloride. Their cyclic voltammetry studies revealed that electroreduction can proceed very quickly indeed, although perhaps at higher current densities than would be viable on the industrial scale. Nevertheless, the CV studies will provide developers with a fundamental reference against which to match the design of a true industrial process for the mass production of silicon powder by electrolysis. Usefully, as reduction depth and time follow an approximate logarithmic law, this can be used to select for a particular particle size too adding to the versatility of the process.

At the time of writing, the team was optimising their electrolysis process.

Further reading

Electrochemical Preparation of Silicon and Its Alloys from Solid Oxides in Molten Calcium Chloride. Xianbo Jin, Pei Gao, Dihua Wang, Xiaohong Hu, and George Z. Chen. Angew. Chem. Int. Ed. 2004, 43, 733-736

Women in Science – Cracks in the Glass Ceiling?

Women often just don’t get it – recognition or high-ranking positions, that is. Vertical segregation is the trendy sociological term, but while the proportion of female graduates in many scientific disciplines has shot up, the proportion of women reaching the top is still low. In most European countries women occupy fewer than one in ten top slots in science faculties.

Mookambeswaran ‘Viji’ Vijayalakshmi is head of a bioengineering laboratory at the Compeigne University of Technology in France. Recently, she became the first winner from France since 1985 of the ‘International Excellency Award’ in the field of affinity technology and biological recognition. Viji, however, is aggrieved that her University failed to communicate the news to the media positively. ‘They did not want to mention my name or my identity as head of this lab,’ she says, ‘nor even to mention the research field…the local press was not even present during the award ceremony.’ Is this a case of unwitting discrimination?

So, what is going on? Haven’t those tough old glass ceilings long since been smashed and piled up in scrapheaps along with that other structural blunder, asbestos? Seemingly not.

According to Nicole Dewandre head of the European Commission’s ‘Women and Science’ Sector there are several factors that underlie the slower progress of women’s careers in science. Surveys, she has pointed out, consistently show that women scientists more often follow their partners than the converse when a job change is in the offing and women are also more commonly forced to compromise their careers in order to balance the issue of child-bearing and child-rearing. While efforts are made by some establishments to assist with relocation through bridging finance and job offers for partners, the so-called received wisdom is that women follow their men. ‘When women go into the workforce, they almost never have the kind of support that men enjoy – their husbands have lives and careers,’ says Nancy Cox, who is researching the genetic basis of diabetes at UChicago. ‘Fewer men have that kind of support either, but there are still some that do, and that it’s difficult to break standards set in a different time.’

A disturbing study in 1997 funded by the Swedish Medical Research Council by microbiologist Christine WennerÃ¥s and immunologist Agnes Wold (Nature, 387, 341) uncovered that there is a strong gender bias in the way research funds are doled out. ‘The system is revealed as being riddled with prejudice…’ the authors claimed. It became apparent that women needed to be at least twice as productive to reap the rewards. The revelation has prompted greater interest in the issues. An inspired EC conference in April 1998 determined that beyond the need to be fair to women, the promotion of women in science is crucial to European society as a whole. The EC has now set itself a 40% target for female participation in its Fifth Framework research program and the pressure is on to ensure women are fairly represented and represent fairly the program’s expert committees. Currently, however, only 15% of applications are from women although the Sixth Framework rather optimistically expects to achieve 50% women participants.

Nancy Lane a cell biologist at the University of Cambridge believes women represent a ‘huge untapped economic potential’. She says as few as 3-4% of UK professors in any branch of science, engineering or technological disciplines are women while the number of women Fellows within the hallowed halls of the Royal Society and the Institute of Biology are, astoundingly, well below 10%. ‘Things are being done,’ she says, ‘but the culture takes a long time to change and many obstacles relating to the ‘old boy network’ still remain.’ Various initiatives are in place, such as the Women’s SET Unit at the Office of Science & Technology, a UK government department. Lane and colleagues are now establishing a Code of Practice for laboratories.

Statistics from the UK’s Royal Society of Chemistry reveal that the percentage of female graduates is higher in chemistry than in physics and mathematics but is lower than in biology. Non-science subjects, such as French and English, still beat the sciences by a wide margin. The female to male ratio of undergraduates in the biological sciences is roughly 50:50. The percentage of females achieving higher degrees in chemistry is smaller than at first degree but it is increasing. US government statistics reflect something similar for the sciences in general, showing that women are approaching half of science and engineering bachelor’s degree recipients having been steadily increasing since the 1980s.

But degrees don’t always facilitate career progression. We are still seeing a strong gender bias. The first full female chemistry professor in the UK, Judith Howard of Durham University, only took her chair in 1991. In chemistry, there were a mere 0.8% females. Extrapolations see no parity between male and female professors existing before the year 2120!

So, where are the women in the upper echelons of science? There are a few famous names admittedly but women seem to remain footsoldiers or else leave the ranks altogether when faced with a lack of professorships available to them. There is a well-worn argument that science, with its goal-oriented attitudes and methodology is a more masculine than feminine pursuit. Women are said to be more interested in finding ways to reach a solution and in learning from the experience whereas men tend to gain more from getting the results and disseminating them in order to gain peer recognition. But, this argument relies on the archaic white-coated male stereotype. ‘I don’t think the problems women face in science and academia are so different from the problems they face in trying to move into the upper echelons anywhere else,’ says Cox.

Some commentators believe it will take more than conferences and proposals to eradicate inherent and ancient sex discrimination in society. According to Anthony Engwirda of Griffith University, Brisbane, Australia, the underlying reason that there are so few women in positions of power is purely historical. ‘When a woman, her mother and her grandmother have no memory of personal discrimination then we could justify a belief about the integration of equal rights,’ he says. The duration and prevalence of an idea might hint at the difficulty in revoking it but, adds Engwirda, ‘changes to society are difficult and take time, the right of a woman to equality must become a pervasive global idea for several generations before the concept becomes self-perpetuating.’

Lane emphasises that women have been waiting for more than a decade to see a gradual filtering of women up through the system. It has not yet happened. Some argue that women are excluded from male lobbies, so have to work harder to get what they need, something certainly confirmed by the 1997 Swedish report. Viji recounts a half-serious comment she heard from a colleague – ”Decisions are so often made in the ‘washrooms’ among men that women can do nothing but be excluded from participating in the decision making process.” Cox adds that, ‘Women scientists are often underestimated because we are more social,’ she says, ‘which can make it harder to recognize that you are serious.’

Time will tell if the huge number of women in biological sciences as students now will rise to populate academic positions higher than assistant professor,’ affirms Karen Cone, a geneticist and molecular biologist at the University of Missouri-Columbia and joint owner of the WiS net discussion group. ‘We still have a long way to go, and the prospects for the “harder science” fields of chemistry, engineering, math and physics have a steeper climb because the number of women choosing to enter these fields at the college level is incredibly low.’

It is not so long ago that society created a stifling atmosphere for women aspiring to engage in scientific research. Collaborations with male colleagues were almost a necessity for women’s research to be heard. The astronomer Caroline Herschel relied on her brothers William and John to disseminate her research results. While archetypal role model Marie Curie received the Physics Nobel apparently on the insistence of her husband Pierre who would not accept it alone. Mme. Curie, of course, won the Chemistry prize in her own right after her husband’s death.

Society frowned on women in science – taunts of ‘unladylike behavior’, ‘immodesty’ and worse were bandied about, according to physicist Gina Hamilton – a staff astronomer at the University of Southern Maine – writing in Physics World recently – the goading still goes on, albeit the language is more ‘modern’. Hamilton adds that while various efforts have been launched, in the US and elsewhere, to increase the number of women studying university science these ‘well-meaning attempts are often frustrated by the reality of the numbers game’. In the more mathematically inclined physics and astronomy, there are simply not enough women with the right skills, who are interested in entering the field.

It is not all doom and gloom. At the Southwest Foundation for Biomedical Research, a non-profit private research institute, the departmental chair of virology and a leading scientist in the department are both women. These are prestigious positions considering there are only four such labs in the country she says.

Bioinformatician Fiona Brinkman of UBC, Vancouver, believes she has benefited from having female role models, however, ‘My PhD supervisor was a woman, and was head of a section of the Canadian Laboratory Centre for Disease Control and a Pan-American Health Organization project, before taking a University Chair,’ she says. She also reveals that her mother was a technician in a scientific field. ‘I believe without really realizing it, I have chosen to be around suitable role models,’ she says.

Hazel Moncrieff meanwhile working in the labs of Bristol-Myers Squibb in England is also more positive about the issue. ‘I have not been put off applying for jobs since the jobs I would be looking for would require technical qualifications which are equal irrespective of gender.’ She adds that within her company most people are BSc/PhD qualified and she does not sense any obvious gender bias. Women, she says, are well represented in management although maybe not at the director level. ‘I don’t think this is due to a direct gender bias but is rather attributable to a wider issue of not affording flexibility to workers.’

Isolated examples are not enough, things may truly have moved on little since the Herschel’s day. Perhaps it is all about mobilization. Maybe action plans will create integration, but nothing substitutes for the involvement of women scientists. All the initiatives, committees, proposals and schemes in the world only make sense and deliver results if women are involved and make their voice heard.

This article originally appeared in BioMedNet’s HMSBeagle in my regular Adapt or Die column.