Melamine Milk Update

UPDATED UPDATE: Two men have been served a death sentence for their involvement in China’s melamine contaminated milk scandal. The former boss of the Sanlu dairy at the centre of the scandal was given life imprisonment. 19 other sentences handed down by the court in northern China, where Sanlu is based, are of lower severity.

More than 200 families whose babies were hospitalised after drinking infant milk formula tainted with the industrial chemical melamine are taking their case to China’s highest court after being repeatedly ignored by lower courts, according to an AP report.

An earlier report revealed that the parents of an infant who died after drinking melamine milk have been paid 200,000 yuan (about $30,000) in compensation by the dairy company at the heart of the scandal, New Zealand owned Sanlu.

A report from Reuters says that the contaminated milk powder killed at least six children and sickened almost 300,000 last year. Many parents whose children were affected are hoping those responsible for the contamination will face the death penalty.

Now that the scandal is not so prominent in the media, investors are moving back in on China, Farming UK reports that Henry George Roberts company KKR & Co intend to invest US$100 million into the dairy industry in China. “Investing in China’s largest producer and distributor of fresh milk, the American company are gambling on the recent melamine scandal being behind them,” the magazine says. “The recent scandal in China over the use of melamine in milk, to raise the protein levels, has seen the values in the industry plummet.”

Reuters and others report that China now plans to impose production controls on melamine so that the melamine in milk scandal may never happen again. At the height of the debacle hundreds of products, not just infant formula, on supermarket shelves across the globe were tainted with the “Made in China” label. Thousands of visitors to the Sciencebase site over the last few months have arrived to get more information as the story unfolded. I will report on any subsequent developments as soon as they happen.

Leukemia Tweezers

stained-leukemia-cellsThe first 2009 issue of SpectroscopyNOW is now available:

Tweezing out leukemia spectra – US researchers have used laser tweezers Raman spectroscopy (LTRS) to help them characterize the effects of different chemical fixation procedures on the spectra of healthy cells and leukemia cells and to avoid the misinterpretation of data.

Crime and punishment – A truly interdisciplinary collaboration between biology, law and neuroscience at Vanderbilt University has used functional magnetic resonance imaging, fMRI, to watch how the brain changes when a person thinks about crime and punishment.

Folding issues – NMR spectroscopy is helping US chemists work out shorter and simpler routes to protein-based drugs for treating a wide range of illnesses including diabetes, cancer, and hepatitis.

By Jove, it’s hot and steamy – In 2007, astronomers discovered that a scorching-hot gas planet beyond 63 light years from our solar system is steaming with water vapour, now, it seems the planet, a hot Jupiters, also suffers from high carbon dioxide levels in its atmosphere.

Opal reversal – Electrochemically oxidizing and reducing an inverse polymer-gel opal causes it to swell and shrink, which alters the wavelength of the light it diffracts brightly, from ultraviolet through the visible to the near infrared, the material could pave the way to new display and monitor technologies.

X-rayed dinobird – Researchers at the SLAC National Accelerator Laboratory used the Stanford Synchrotron Radiation Lightsource (SSRL) to shine intense X-ray beams on the so-called “dinobird” to reveal chemical secrets that have been hidden from view for millions of years.

How Alternative Medicine Fails Us

rhodiola-roseaI’m forever fending off the alternative medicine brigade who seem to clump around this website and email me all kinds of supposed miracle cures that will spell the end of all health ills. One herbal remedy I recently focused on is Rhodiola rosea, in which I critiqued a promotional email from a vested interest in the product. They made all kinds of claims for this material on the back of very limited clinical trials. Needless to say advocates of alternative medicine commented aplenty.

As a chemist, I take what I hope is a healthy and skeptical view of all the biochemical and physiological claims these people make for their products. I’m just worried that there are so many people who are perhaps desperate to fix their lives that they become easy prey for such marketing. Anyway, for those who feel a chemist has no place criticising their beloved remedy, I turned to a pharmaceutical expert in Sheryl Torr-Brown of the Future Trends in Health blog to provide some additional support for my argument. She has many years experience in pharmaceutical science and has no axe to grind and offers an honest appraisal of my original post and some of the comments left by Sciencebase readers.

A glance at the scientific literature covering this herb seems to be minimal and biased in the main, she told me, and as such she agrees with my argument.

“When dealing with alternative medicine,” she says, “it is not enough to be right if you want to avoid the attacks. You also have to be sensitive to the highly personal views of those who find benefit in the drug albeit most likely due to placebo effect.”

This is perhaps an important point. Yes, the placebo effect is valid, but these remedies are usually very expensive and people are often spending their hard-earned money on what amounts to sugar pills, something that should be avoided perhaps especially in the current economic climate when every penny counts.

“A major point that most of the non-scientific public do not understand is that there is no such thing as a safe drug, natural or not,” adds Torr-Brown, “The dose is the poison, as the father of modern toxicology, Paracelsus said in the fifteenth century. Anything and everything will be toxic if you have enough of it or it gets into the wrong place. Unfortunately, people are tired of Big Pharma advertising and the media frenzy around drug withdrawals.”

She points out that ‘natural’ is sounding better and better to many folks, despite the existence of natural belladonna, natural cobra venom, oh, and natural background radiation. In the age of the Internet, it is now very easy to get positive anecdotes about anything. “Basically, one can decide what one wants to believe and then go find the evidence to support it,” Torr-Brown adds, “For scientists, we look for controlled studies to prove a point, whereas the general public are happy with a personal story or two of success.”

Many people, including several of the original, negative commenters on my R rosea post, are grasping to find something that works for them. “You cannot discount [some of these views] from a human perspective, but it makes no sense scientifically, adds Torr-Brown, “I am shocked by the number of people I know who pay huge amounts of money for the latest panacea only to give it up after a couple of months, usually due to lack of interest.”

  • Innocent children and the most vulnerable can be hurt the most
  • £200m boom as demand for ‘natural’ cures soars
  • Rhodiola rosea
  • How not to do a study on the efficacy of “alternative” medicine
  • Rhodiola rosea

Sperm, Discharge, Heroin, and Alzheimers

alkaline-batteriesBatteries are included (unfortunately) – A chemical cocktail of toxic gases is released when you burn alkaline batteries, according to the latest research from Spain. The investigating team highlights the issue with respect to municipal waste incineration, which is used as an alternative to landfill and suggests that recycling is perhaps the only environmentally viable alternative.

Today, UK government departments BERR and Defra, in conjunction with the Devolved Administrations,
today published a Consultation Document containing draft Regulations setting out proposed systems for the collection, treatment and recycling of waste portable, industrial and automotive batteries.

Cutting heroin analysis – Analysing samples of street heroin just got easier as researchers have developed a statistical method for removing uninformative signals from their near-infra-red spectra of seized samples.

Sperm and eggs – Scientists in Sweden have determined the precise molecular structure of a protein, ZP3, essential to the interaction of the mammalian egg coat and sperm. The work could eventually lead to improved contraceptives, has implications for fertility studies, and might, in some sense, explain how new species arise.

Untangling Alzheimer molecules – Magnetic resonance spectroscopy provides new clues about how a dipeptide molecule blocks the formation of the toxic amyloid beta-peptide aggregates in the mouse brain. The discovery could put paid to the theory that amyloid beta-peptide causes Alzheimer’s disease and suggest a therapeutic lead that focus on the real culprit at an earlier stage.

Alchemy Under the Spotlight

atlantic-bathymetryThis week, The Alchemist is digging in the dirt to find out about the carbon cycle and climate change, taking his whisky (or is it whiskey) with or without water, and discovering how to juggle molecules, on the other hand. Also in biochemical news this week, the crystal structure of a plant hormone receptor is revealed while researchers in Israel focus on blocking the protein misfolding that occurs in Alzheimer’s disease.

And, under the December physical sciences Spotlight

It’s all in the marine mix – Mixing of surface waters in the Atlantic Ocean seems to have reverted in the winter of 2007/2008 to “normal” levels for the first time in almost a decade…

Well, wooden you know? – New materials that look and behave like plastics can be produced from a renewable raw material known as liquid wood. The bioplastics promise to displace petroleum as a feedstock for certain applications…

Running with knives – Stabbing is the most common form of murder in the UK and Ireland. However, while forensic scientists understand the basics of the process…

Rx Reviews Redux

A new(ish) website has launched that aims to provide unbiased patient-generated data on the benefits of 7000 prescription medications and their side-effects.

Rateadrug.com hopes to do for pharma products what dooyoo and ciao do for gadgets by bringing the crowd to the debate. Patients can anonymously rate and review any of the prescription drugs they take and view other people’s experiences for free.

“All information on this site is unique, community data that is not biased by pharmaceutical or corporate objectives,” says spokesman Jack Dowd. He adds that, “The site provides patients with truly independent survey results about the risks and benefits of their medications. The more people that start using the site to rate their prescription medications (a quick 5-minute survey), the greater this resource will become.”

Using a prescription drug appropriate to your condition and your genetics can have significant, and often life-saving benefits, but with physicians particularly in the UK and a few other places emphasising how patients should help manage their own illness it is important to know what problems may arise or whether asking for a different prescription might actually be better for them.

Not all medications hit everyone in the same way, because of various factors including your SNPs (single nucleotide polymorphisms), that affect your body’s enzyme and receptor activity. “What’s effective and side-effect free for one person might not be the best drug for someone else, yet most harried doctors prescribe the same drug for 90% of their patients with similar conditions – regardless of individual sensitivities,” the site’s developers say. They hope that Rateadrug will prevent the next Vioxx from happening.

A side project of Rateadrug is involving pre-med students through the PreMed Prescription Rating and Experience Program (PREPP) where the students help senior citizens become more proactive with their drug intake by reporting their experiences through Rateadrug.com.

The site blurb suggests you use the reviews together with your doctor’s advice and FDA disclosures to achieve the best possible outcome for your (or your loved ones) medical condition. Of course, spammers and corporate shills will be readying themselves to distort the results in their favour, unless preventative measures are put in place. “To prevent spam and ensure a real person is taking each survey we require email verification where the user has to click on a link that we email to them,” Dowd told Sciencebase, “We also flag accounts that submit more than one rating for a specific drug. We’re committed to providing quality, real-user data and will continue to ensure that our results are not skewed by spam or anyone trying to influence the results of a specific drug.”

The site also drops a cookie on to your machine so that it knows how many people log in from a specific computer or IP address. If it looks like there are a lot of ratings for the same drug from the same IP address, they will flag those ratings for manual checking.

I asked Dowd to expand on how they are addressing security and validity issues. “At the moment we receive 20 or fewer ratings per day, and carefully review each one,” adds Dowd, “As the volume increases significantly it will become more difficult to impact and distort results – real ratings should outweigh any attempts to skew ratings. But, we will do our best to prevent this type of tampering.”

“Right now, we have a database of over 7000 drugs, but only about 300 have been rated and reviewed by users/patients,” he adds. Dowd and his colleagues hope that as more people find out about this site, the numbers will grow. “Our intention is to provide real ratings by real people and will do everything we can to assure this as we progress,” he told me.

According to CEO Mark Deuitch, RateADrug is currently hoping to get large numbers of patients to review the cholesterol-lowering statin drugs Lipitor, Lescol, Mevacor, Pravachol, and Zocar, anti-depressants such as Lexapro, Prozac, Effexor, Paxil, Zoloft, and Pristiq, and drugs used to treat insomnia including Ambien, Lunesta, Sonata, Rozerem, and Benzodiazepines.

In related news from the UK’s National Health Service: Drug reference information in the British National Formulary will become a key element of the new NHS Evidence portal due to be launched in April 2009. As a result, responsibility for provision of this information for the NHS will transfer from the Department of Health to the National Institute for Health and Clinical Excellence (NICE), as part of the development of NHS Evidence.

Top Ten Mutants

dna-testIf you ever thought genetics was only about disease, then check out the popular SNPs list on SNPedia. A SNP (pronounced “snip”) is a single nucleotide polymorphism, which in BradSpeak(TM) is basically a difference in a bit of your DNA that makes you different from the rest.

Anyway, here’s the Top Five SNPs that might be described as having no obvious direct medical importance.

  • rs1815739 sprinters vs endurance athletes (I reckon I lack both)
  • rs7495174 green eye color and rs12913832 for blue eye color
  • rs6152 can prevent baldness (this was discovered far too late for me)
  • rs1805009 determines red hair (some “comedians” might suggest this be swapped to the second list below)
  • rs17822931 determines earwax (and presumably how well your ears stay clear of insect infestation)

And, here’s the more sober list of SNPs that could have serious medical implications should you happen to discover you have one of these when you have your genome read by the likes of 23andMe.

  • rs9939609 triggers obesity (not a genetic excuse for eating too much)
  • rs662799 prevents weight gain from high fat diets (ditto)
  • rs4420638 and rs429358 can raise the risk of Alzheimer’s disease by tenfold or more
  • rs7903146 and rs12255372 linked to type-2 diabetes, the latter also to breast cancer
  • rs324650 influences alcohol dependence, rs1799971 makes alcohol cravings stronger (it would not be funny to say, “Mine’s a pint, with a whisky chaser”, right now)

It was a twitter discussion between SNP experts mza and attilacsordas that led me to the SNP list.

Shedding Light on Neon Signs

neon-signAs regular readers know, I like to keep a fairly close eye on what Sciencebase visitors are searching for so that I can put together new posts that provide answers to the questions readers want answering. Recently, there has been a spate of search queries related to neon signs. Perhaps not the most exciting of subjects, but there is some nice chemistry to be learned from all the different colours available, so I thought I’d shed some light on the subject of noble gas illumination.

Incidentally, for those unaware of the history of noble gases, they were at one time known as inert gases because chemists thought their full outer shell of electrons made them unreactive. As more and more reactions for these so-called inert gases were discovered, it became necessary to abandon the “inert” label and focus on their nobility.

A neon light is not really much more than a fluorescent tube (actually, it’s less as it needs no phosphor coating on the inside), neon tubes contain the noble gas neon, surprise, surprise. Pass an electric discharge through a tube containing low pressure neon and it will glow with that familiar orange-red glow, so evocative of late-night bars and sleazy movies.

A neon light uses a very high voltage to propel an electric current through a low-density gas of neon atoms held in a glass tube. Charges from the electrode at each end of the tube fly through the gas colliding frequently with neon atoms and transferring some of their energy to the neon atoms. This kicks the neon atoms into a higher energy, excited state, with an electron in a higher orbital than normal. This excited state does not last and as the electron loses energy the atom drops back to a lower energy state and releases a photon of light. The energy of this photon is equivalent to the energy fall and for neon atoms that coincides with an energy that produces a reddish glow.

Many people, unfamiliar with the noble gas group of the periodic table – the p-block, assume that all coloured fluorescent tubes used in signage are neon signs. However, there are two ways to produce other colours – paint a standard mercury tube with the colour you want or far more effectively use a different noble gas in the tube instead of neon, perhaps together with mercury vapour to give a stronger glow. Here’s a break down of the discharge colours for each noble gas.

Helium (He) – Orangey white, usually
Neon (Ne) – Orange-red glow
Argon (Ar) – Violet, pale lavender blue
Krypton (Kr) – Grayish dim off-white
Xenon (Xe) – Blue-grey
Radon (Rn) – radioactive, not used in lighting

Of course, it is not only the noble gases and mercury vapour that can be added to lighting tubes. Nitrogen produces a slightly pinker glow than argon, oxygen glows violet-lavender but dimly. Hydrogen glows lavender at low currents, but pinkish magenta above 10 milliAmps, while carbon dioxide produces a slight bluish-white. Mercury can be made to glow in the ultraviolet, and is used in so-called black lights. Sodium vapour at low pressure glows the bright yellow of street lighting, particularly in England. And, even water vapour produces a glow similar to hydrogen, only dimmer .

Breast is Best in Melamine Scandal

breastfeeding-babyThe melamine in milk scandal continues to draw interest. You recall, across Asia, in particularly in China, infant formula milk was discovered to be contaminated with a starting material for making plastics and fire retardant materials, melamine. Thousands of babies were hospitalised with possible renal failure, and several died.

But, could some good have come out of this scandal? Apparently, breast-feeding rates have bounced back across Asia, according to some reports and a roundtable, Secure nutritious diet: Save children’s lives, organised jointly by Save the Children UK and others is using the melamine scare to help promote the breast is best message. It has been demonstrated time and again that breastfeeding reduces infant mortality rates particularly in the developing world. One wit even suggested that the melamine contamination was done deliberately to promote breastfeeding, a nonsense, obviously.

Others are now reporting that the formula manufacturers are hoping to restrict this renewed enthusiasm for breastfeeding by heavy promotion of their products even if they are in breach of WHO guidelines on marketing of breast milk substitutes.

Others benefiting from the melamine scandal, although not in the same cynical way are chemical analysis companies, who, according to the Boston Globe are seeing improved business as food safety scares raise the profile of state-of-the-art testing equipments, including melamine test kits. The Gainesville Sun even reported on a woman who had developed her own testing kit for melamine.

As was mentioned in a comment on a previous melamine post, the US FDA has updated its import alert on melamine: “Detention without physical examination of all milk products, milk derived ingredients and finished food products containing milk from china due to the presence of melamine and/or melamine analogs.”

Virtual Rehabilitation for MS Sufferers

I recently wrote about how social media might help scientists do their work, so a paper in IJWBS on how those on the receiving end of medical science – patients and healthcare practitioners – might benefit from web 2.0 caught my eye.

IT consultant Maire Heikkinen of University of Tampere, Finland, has focused on how the internet might be used in rehabilitation courses for sufferers of long-term neurological diseases including Multiple Sclerosis (MS).

Today, more than 2,500,000 people have MS, a disorder that affects different areas of the central nervous system and so leads to a wide range of symptoms from blurred vision and numbness to weak limbs, unsteadiness, and fatigue. Periods of relapse and remission are often characteristics of the disease but for other people the disease progressively worsens. Either way, it can limit everyday life seriously and makes for an uncertain future for sufferers and those close to them. “There is no known medical cure,” Heikkinen told Sciencebase, but medicine can help moderate the symptoms and prevent relapses, and rehabilitation can help people considerably.”

Getting hold of useful information about one’s disease, discussing problems, and following rehabilitation schemes, is Heikkinen explains an essential part of the process of healing.The rehabilitation for MS patients has traditionally been face-to-face courses and personal physiotherapy, but the internet has enabled some forms of online rehabilitation.

She has looked at the concept of a virtual community for rehabilitation and, in particular, the opportunities for sociability among participants. She found that peer support and the swapping of experiences were the most important part of the online activities. But, perhaps most intriguingly, the MS patients in her study seemed to have a higher trust level among themselves than is common in some online activities. The participants apparently preferred to get to know each other rather than operating anonymously as is common on other internet rehabilitation and support courses, those for cancer sufferers, she cites.

The internet course Heikkinen studied was “Power and Support from the Net”, which was organised by the Finnish MS Society. While there are those who claim that such virtual communities are somehow worth less than face-to-face contacts, others point out that circumstances and ill-health often prevent people from making direct social contact. It is the virtual nature of “online” that seems to offer a significant advantage in a virtual rehabilitation community, in that people are often more willing to discuss problems online than they would be in a face-to-face meeting.

There is evidence that being online is not the depressing default state that those railing against it would have us believe. Heikkinen’s study certainly suggests this is true with regard to outcomes for MS sufferers involved with PSN.

The internet was shown to be a suitable tool for arranging rehabilitation courses for MS sufferers, she says. The course team could build a virtual community at least for the duration of the course, but it will also be possible to continue the team after the course. The course may thus serve as an initiator for a longer-lasting virtual team that will exist for as long as the participants stay active.

Various researchers have outlined the benefits of online community in the past. Virtual communities are inherently social networks because at the base level they link together people, organisations and knowledge. They can become integrated into our daily lives and, as anyone with an active web 2.0 account knows, the internet can increase our contact with friends, relatives, and other contacts regardless of geography, time, or state of health. Fundamentally, adds Heikkinen, “When computer systems connect people and organisations, they form social networks.”

Maire Heikkinen (2009). Power and support from the net: usability and sociability on an internet-based rehabilitation course for people with multiple sclerosis Int. J. Web Based Communities, 5 (1), 83-104