Frogs legs and AMPs

Antimicrobial peptidesSolid state NMR is unlocking the secrets of compounds found in natural membranes from frogs’ legs to human lungs that could lead to an entirely new class of antibiotic drugs. The compounds in question are antimicrobial peptides (AMPs) and they have been detected in every living creature studied so far. AMPs act as a first line chemical defence system in a huge range of organisms and could provide a novel approach to defeating drugs resistance in bacteria.

“Our overall mission is to use the kind of basic physical data we obtain from NMR to help interpret biological functions,” team leader Ayyalusamy Ramamoorthy of the University of Michigan explains. As with most discoveries of this nature, it will be several years before any clinical trials for specific health problems or diseases are complete. “How it works against viruses are under investigation in other labs,” Ramamoorthy told me.

You can find out more about AMPs as the front line defenders in the latest issue of SpectroscopyNOW.

Are you at risk of diabetes

Diabetes testBoth the UK and US national diabetes organizations have a risk test available for anyone worried about diabetes risk. Read the rest of this post and then take the tests and let me know how you get on.

You can take the Diabetes UK MeasureUp two-minute test here and/or the US diabetes risk test, although I recommend the more comprehensive (but more complicated) Diabetes UK test.

The US test is very, very simplistic, it asks you to plump for a very broad age range, asks if you have siblings or parents with diabetes, gets your height and weight, and whether you excercise or not. There is no detail in the questions at all, but then the results are very simplistic too. I truthfully filled in the blanks and scored a big fat zero. Null points. Thankfully, that means very low risk. But, I think the lack of questioning about supine waist measurement, body fat percentage and actual details about exercise, blood pressure etc, mean one would have to take this result with a large pinch of salt (actually, hold the salt, throw some sand instead, it is healthier).

I realize this is more about awareness and the tests are deliberately simplistic so that someone with a family history who does not exercise and is overweight might hopefully visit their doctor for a check up when the test shows them to be high risk.

There are over 20 million people in the US with diabetes, says the ADO, and almost a third of those (more than 6 million people) do not know it. These people need to get equipment and help for their disease like a glucometer by Dexcom.”

In contrast, the UK test is much more comprehensive and so presumably provides a better reflection of risk, it asks for waist measurement as well as ethnicity, and whether you have any cardiovascular disorders in some detail. It also asks about mental health and known metabolic disorders, as well as factors such as mental health problems. With all this additional information I still came out low risk, so I’m happy. What about you? I’d be interested to read comments from Sciencebase visitors who try either or both tests. Remember though, that if you are worried about diabetes or show any symptoms of the disease get to your GP fast.

Further information on diabetes is available from American Diabetes Association and Diabetes UK

Mass debate on stem cell research

Embryonic stem cellsJust £300,000 (about $600k) is being plugged into a national public debate by the UK government on stem cell research. According to Science and Innovation Minister Malcolm Wicks the UK’s two major public funders of stem cell research will use the cash to run a national public discussion about this cutting-edge area of science.

The Biotechnology and Biological Sciences Research Council (BBSRC) and the Medical Research Council (MRC) will receive the funding as part of the government’s ScienceWise initiative. The aim will be to find out what are the public’s concerns, views and attitudes to this face-most moving area of science. It will also provide a forum for revealing the challenges that researchers face and the potential benefits of stem cell science.

At today’s launch Wicks said: “The Government believes that stem cell research offers enormous potential to deliver new treatments for many devastating diseases where there is currently no effective cure. Huge numbers of people are affected by these diseases and Britain is a world-leader in stem cell research. But there must be a proper dialogue with the wider public on the future of stem cell research. We need to raise public awareness about the potential opportunities
and challenges in this area.”

One key element of the initiative is to raise awareness of the world-class stem cell
research being carried out in the UK, at centres such as Newcastle University, and the progress being made towards practical treatments.

BBSRC’s Julia Goodfellow added, “It is essential that scientists working in areas such as stem cell research engage in a real dialogue with the public. The new programme will give scientists, funders and the government up-to-date information on what the public really think about stem cell research while giving people the chance to voice their views and concerns.” So, basically repeating what Wicks said. The MRC’s chief Colin Blakemore, had a slightly different slant. “Scientists who work
on stem cells want to ensure they maintain the trust and support of the public for their research,” he said. “But to achieve this, we need to explain what work is being carried out and why it’s being done.”

So, is £300,000 enough to do the job? Compare this with the ludicrous amounts of money available to anti-science type lobby groups which amount to millions and it really does look like a pittance. Half of that amount could easily be eaten up by an independent designer putting together a corporate logo for the project and the other half will have gone on snacks and wine for the launch party buffet, or am I being far, far too cynical? You tell me.

Natural Family Planning

Natural family planningCould the contraceptive pill be replaced by a “natural” approach to family planning? It could if a study by Petra Frank-Herrmann of the Department of Gynaecological Endocrinology at the University of Heidelberg, Germany, proves reproducible (pardon the pun).

She and her colleagues have demonstrated that using two indicators for the fertile period in a woman’s menstrual cycle and avoiding unprotected sex during that time is just as effective as the contraceptive pill for avoiding unplanned pregnancies. The study was published in Human Reproduction this week.

The symptothermal method (STM) uses temperature and cervical secretion to pinpoint a woman’s fertile time. The German team carried out the largest prospective study of the method yet and found that if couples abstained from unprotected sex during this time the rate of unplanned pregnancies per year was 0.4% and 0.6% respectively. Out of all the 900 women who took part in the study, including those who had unprotected sex during their fertile period, 1.8 per 100 became unintentionally pregnant.

“For a contraceptive method to be rated as highly efficient as the hormonal pill, there should be less than one pregnancy per 100 women per year when the method is used correctly,” Frank-Herrman explains, “The pregnancy rate for women who used the STM method correctly in our study was 0.4%, which can be interpreted as one pregnancy occurring per 250 women per year.”

The authors were also surprised by the relatively low rate of unintended pregnancies (7.5%) among women who had unprotected sex during their fertile period. ‘If people are trying for pregnancy you expect a pregnancy rate of 28% per cycle,’ said Frank-Herrmann. ‘Therefore, we think that some of the couples were practicing conscious, intelligent risk-taking, and were having no unprotected sex during the few highly fertile days, but had unprotected intercourse on the days at the margins of the fertile time when the risk of pregnancy was lower.’

Medical marijuana

Cannabis leaf“The US Food & Drug Administration’s (FDA) position on medical cannabis is incorrect, dishonest and a flagrant violation of laws requiring the government to base policy on sound science,” claims Joe Elford, Chief Counsel for patient advocacy group. The organisation, the largest of its type in the US promoting safe and legal access to cannabis for therapeutic use and research, has filed a lawsuit demanding that the federal government “cease issuing misinformation on medical cannabis and correct the information it has released.”

There is growing evidence that the active ingredient in cannabis (THC, or tetrahydrocannabinol) can alleviate the often debilitating pain suffered by those afflicted with multiple sclerosis (MS) and HIV/AIDS. However, given the drug’s illicit status in most countries many governments have not acceded to its free use as a therapeutic agent nor encouraged systematic research and clinical trials to demonstrate efficacy or otherwise. Moreover, the ASA suggests that the US government is stifling valid research and spreading disinformation about the benefits.

The pharmacological action of THC results from the compound binding to the so-called cannabinoid receptor CB1, in the brain. The presence of this specialized receptor suggests that there are natural THC-like (cannabinoid) compounds made or used in the body. THC has been repeatedly demonstrated to have analgesic effects but the “high” associated with its use have precluded it from mainstream medical research. Several research teams are, however, investigating variations on the THC theme that retain the analgesic properties but do not produce a high. Such a product would be more acceptable to the pharmaceutical industry and the regulatory authorities, but requires a lot of work with the native compound to help scientists work out what chemical factor leads to the high and which part produces just the analgesic effect.

Fellow blogger “Joe” discusses many of the issues in more detail. He points out that since the 1980s the FDA has actually approved Marinol, a synthetic THC analogue for pain in cancer. But, the conflicting response of successive Bush adminstrations (viz the first Bush administration, in the early 1990s cancelled a compassionate use program and in the late 1990s, the Office of National Drug Control Policy threatened action against physicians who recommend or prescribe marijuana. California doctors and patients subsequently sued the federal government.

Opponents of medical marijuana use cite apocryphal evidence that it is a gateway drug to harder substances. However, one must consider the plight of terminally ill patients who seek relief from intolerable pain and suffering. Ironically, many terminally ill patients do indeed end up using much harder drugs in the end. Diamorphine? Heroin by another name.

Antioxidant buzz

Honey beeBees making honey from honeydew rather than nectar produce a sweet material that has greater anti oxidant properties than nectar honey, according to a study of 36 honey samples from Spain with different floral origins. The study published this month in the Journal of the Science of Food and Agriculture could point to a way to improve the health benefits of this natural sweetener.

The composition of honey depends greatly on where honeybees collect their raw materials. There are two key sources. Honeybees can collect nectar from flowers, and this generates nectar honeys or they can collect fluids exuded by plants, honeydew.

‘Honey is a natural source of antioxidants, and among honeys, honeydew honey is the best,’ says researcher Rosa Ana Pérez, who works at the Instituto Madrileño de Investigación y Desarrollo Rural, Agrario y Alimentario, in Madrid, Spain.

Each of the 36 honeys was exposed to a range of physical and chemical tests. Honeys with high antioxidant properties also had high total polyphenol content, net absorbance, pH and electrical conductivity.

‘These laboratory results show some aspects that people could use to get an idea about which honeys are likely to have the most potent antioxidant properties,’ says Pérez.

Oxidation is a chemical process in which electrons are transferred from from one substance to an oxidizing agent. Antioxidants are basically compounds that slow the rate of oxidation and are as important the chemistry laboratory as they are in the human body. Antioxidants work either by reacting with intermediates and inhibiting the oxidation reaction directly, or themselves reacting with the oxidizing agent and acting as a molecular decoy to prevent the oxidation reaction from occurring.

All living things try to sustain a reducing (the opposite of oxidizing) environment within their cells to prevent damage by oxidation of their biomolecules. Compounds such as glutathione and ascorbic acid (vitamin C) as well as enzymes (peroxidases and oxidoreductases) act as antioxidants. If you do not have adequate levels of antioxidants in your body then oxidative stress and cell damage can occur. More controversial is the notion that supplementing with antioxidants a balanced diet of fruit and vegetables has any additional benefits, claims of anticancer effects and reduced risk of cardiovascular disease have yet to be proved. Indeed, excess of certain antioxidants can do more harm than good.

Bird flu pandemic chokes internet

H5N1 influenzaIf the avian influenza virus, H5N1, ever gets around to mutating into a lethal and virulent form that can be passed on readily from one person to another, then we will be facing a pandemic. Of course, as some observers have pointed out, mainly those without a vested interest in scaremongering, the process of mutation would more than likely lead to a strain of the disease that was not so commonly lethal in people, just as it is not commonly lethal in the natural wild bird hosts.

Anyway, if and when a pandemic pans around, we are likely to see a lot of people either being forced to work from home or opting to do so to reduce the risk of the disease spreading further than it needs to. According to ComputerWorld, this stay-at-home shift could choke the internet as workers and students forced into their homes will no doubt continue to treat even old dial-up accounts as being as fast as their work broadband connections and maintain their interest in high bandwidth sites like Youtube.

ComputerWorld suggests that this sudden burden on bytes will force governments to throttle bandwidth on non-essential services. After all, who seriously will need to watch videos of people hacking 9V batteries apart or powering their mp3 player with sweet potatoes when everyone around them are running around like headless chickens? Well…me for one! If we’re all forced to stay indoors and away from other people, then that will mean no proper TV being made, all we’ll get will be endless replays of turkeys and chickens being slaughtered and medical pundits waffling on about how they told us so. Youtube and social bookmarking sites like Digg and Slashdot could become our only useful information sources, with netizens pulling together to dispel the propagating myths and bring us video clips like the How to Sneeze public service broadcast.

Eat like Grandma, live longer

Chilli PeppersAccording to an article in the New York Times magazine recently, there are nine golden rules of nutrition that in these days of overweight obesics, rising sugar levels, and general all-round fitness collapse, we could all do well to follow. Or, could we?

I’ll list the rules, as compiled by article author Michael Pollan, and re-compiled by Jess3 and then discuss briefly whether the concept is valid or not.

So, here are the rules, in summary:

  1. Don’t eat anything your great-great-grandmother wouldn’t recognize as food
  2. Avoid so-called “health” foods
  3. Don’t eat anything you can’t pronounce
  4. Avoid supermarkets
  5. Never mind the quality, feel the quality
  6. Eat shoots and leaves
  7. Eat in the French, Japanese, Italian, or Greek style
  8. Avoid fast food, by growing and cooking your own
  9. Eat omnivorously, like a dog, not a cat

    So, are these rules valid or not? Broadly speaking yes, but we must remember that our great-great-grandmothers and fathers and those romantic country folk from around the Mediterranean Sea do not necessarily have a lower incidence of heart disease and diabetes nor do they live longer, healthier lives than we may care to think. The average life expectancy of our ancestors was very different from our own for all sorts of reasons and we’re only now seeing changes in health in the Med, Japan etc that are impacted by changes that happened during the twentieth century, such as war and not necessarily the shift to a more “American” diet. This difference in life expectancy is partly due to the fact that infant mortality was a lot higher, death in childbirth was common, disease was rampant, and the availability of food, of poor or high quality, was low.

    As to the Mediterranean diet, delicious yet, but it has not been proved that a diet rich in olive oil, red wine, eggplant, capsicums, and wholemeal pasta is any better than any other diet. Until well after WWII most of the countries around the Med were well below the poverty levels we see, generally, today in the West. There could be a residual effect of this poverty that has provided a buffer to disease from one generation to the next in the last fifty years, but we could soon see an interesting shift in cardiovascular disease among the baby-boomers of the Med in the next few years, perhaps as the poor diet of the grandparents of baby-boomers kicks in.

    Meanwhile, why shouldn’t you eat anything you can’t pronounce? I presume this alludes to “chemicals” in our foods, but I don’t know any two people who pronounce or even spell yogurt the same and as to Brits knowing what zucchini are, I daren’t say. Of course, maybe that’s the point – we shouldn’t be eating yogurt, or any dairy products; after it’s only relatively recently that we started tugging on the teats of bovine mammals. As to chemicals in our foods, there is nothing in any food that isn’t a chemical, we’ve had millions of years to evolve to cope with all kinds of natural toxins and pesticides, so there’s no reason to think that our bodies cannot cope, just because a chemical is synthetic. Moreover, nature is full of natural compounds that we cannot digest and at worst can kill.

    All that said, eating omnivorously, dedicating a bigger proportion of your money to quality food, and avoiding mass produced processed materials, is most certainly a good idea for many reasons other than personal health.

New treatments for COPD

COPD LungsA plea from a Sciencebase reader asking for more information on new treatments for COPD, chronic obstructive pulmonary disease, led me to do a search to find the specific novel therapy the reader mentioned. Apparently, there was a news item on US TV that referred to research in Mexico.

Well, my search turned up several new treatments for COPD. Medical News Today reported in January how combining a long-acting bronchodilator with an inhaled corticosteroid could reduce the number of exacerbations by 35%, but this was work carried out Germany, with no Mexican connection as far as I could tell. Then there were the more recent revelation that helium, the noble gas of squeaky voice fame, combined with 40% oxygen could increase the exercise capacity of patients with COPD by an average of 245%. Again, no Mexican connection, this time the research was Canadian.

A UK and Canadian collaboration has identified an inflammatory mechanism that could explain some of the most extreme symptoms and point to new treatments. Indeed, Imperial College’s Peter Barnes had shown previously that low doses of theophylline, a substance occurring in tea leaves can help relax the bronchial tubes in the lungs and render them more amenable to corticosteroid intervention than they would otherwise be.

It might be that one in ten of COPD flare-ups could be prevented by treating patients with antibiotics to rid them of the bacterium thought to cause these problems in a sub-group of patients.

COPD is the fourth leading cause of death in the US and in January this year the National Institutes of Health put up $13 million to the University of Pittsburgh to help researchers there understand better the disease and potentially find more effective treatments. COPD, some times known as chronic obstructive airways disease (COAD) is most commonly associated with smoking tobacco (you’ve got a hugely increased risk of this disease if you have smoked an average of 20 cigarettes a day for 20 years or more across your lifetime) but the disease can also arise because of coal dust and other pollutants. I say disease, but it’s actually a combination of diseases chronic bronchitis (which is inflammatory, in nature, narrows airways and increases mucus production) and emphysema (destruction of lung tissue).

Still no Mexico connection, not even with a search on NCBI PubMed… Then I received another email from the Sciencebase correspondent who revised the original note to include the word “new” it was New Mexico…not old Mexico. I should have thought of that first off, but I didn’t. However, a quick search with new included brought up the item that I suspect our correspondent had heard about.

Apparently, the Lovelace Respiratory Research Institute is collaborating with Dr Richard Crowell of the Albuquerque Veterans Administration Medical Center to begin a new study over the next three years that will enlist more than 3000 Albuquerque area residents at risk of COPD and lung cancer. Now, this isn’t quite the treatment breakthrough mentioned in the original email, but this looks like another promising lead in dealing with COPD.