Fitting Genes to Obesity Problem

Ana Antón Solanas, a research assistant in the Dietetics and Diet Therapy Unit of the University of Navarra, hopes to tailor diet and exercise regimes to women with specific types of obesity. She has received a fellowship from The Danone Institute to investigate the effects of a hypocaloric diet and physical training in the metabolic and hormonal response in a group of obese women.

The women in the study have a genetic difference (a Gln27Glu polymorphism in the beta2adrenergic receptor) that endows them with a greater body mass index despite exercising on a regular basis. Solanas research does not provide an excuse for obesity. “Our goal consists precisely in understanding the reason that women with this trait are more resistant to weight loss,” she says.

The ultimate aim of the research is to understand the characteristics of obesity that vary depending on such genetic polymorphisms and to develop individualized treatments for each obesity type.

“In the future we will be able to create diets and exercise regimens which are genetically adjusted to the individual person,” she adds.

Keep Eating your Greens

“Research has shown that most essential nutrient deficiencies can be eliminated by small increases in diversity in the diet,” says Dr Emile Frison, Director General of IPGRI (the International Plant Genetic Resources Institute). He stresses that “this has important implications for the health and nutrition of people living in the West, but it is even more important for people living in developing countries.”

The bottom line is that you should put away those health food supplements and simply make sure you eat plenty of fresh fruit and vegetables. But, isn’t this the fundamental advice that we’ve all known for years – “an apple a day,” “eat your greens”, “a rolling stone…”. Okay, that last one doesn’t fit, but the idea of fruit and veg being good for you, and more specifically, better for you than the contents of a pile of blister packs and little plastic bottles, is not just received wisdom, it’s pretty much been demonstrated again and again in scientific studies.

But, there is perhaps more we can do to improve even a diet rich in fresh fruit and veg, according to an IPGRI press release.

Scientists at the Catholic University in Leuven (KUL), Belgium, are working with IPGRI and partners to improve the nutritional qualities of staple foods such as the banana. “There are orange-fleshed varieties in the South Pacific that deliver the complete daily requirement for vitamin A in one banana,” says Professor Rony Swennen, director of the International Transit Centre at KUL. “We’re working to ensure that other people who depend on bananas can get the same level of nutrition from their crops, instead of having to use supplements.”

Supplements can help address specific deficiencies in essential nutrients, but a diet that is diverse offers a more holistic approach to nutrition and health. Buckwheat and finger millet, for example, reduce the risk of heart disease. Other plants contain compounds that can improve the body’s ability to assimilate nutrients and to defend itself against illness. Fenugreek, for instance, contains compounds that help the body to respond to insulin, and leafy vegetables contain antioxidant carotenoids that can prevent damage to cells and tissues. These findings are particularly significant for the developing world’s poor.

IPGRI has launched an initiative to improve the health, nutrition and livelihoods of people in the developing world by promoting dietary diversity. For example, IPGRI has been promoting the use of millets as a way to improve the income and nutrition of farmers in Tamil Nadu, in the south of India. Millets can thrive in marginal conditions, making them easier to grow and better for the environment. They are also nutritious and therefore a healthy option for urban dwellers.

“Affluent consumers are not the only ones who need to combat diabetes, obesity and other diet-related diseases,” explains Frison. “The poor in developing countries increasingly face the same problems and the solutions are the same for them.” The message is clear: diversity is a powerful source of good nutrition and thus, better health.

Fighting Tooth Decay with Licorice

Licorice root could be the dentist’s nightmare come true – a “candy” that actually prevents cavities. Researchers at UCLA have demonstrated that an extract from the plant root used to make all sorts of candies and other products contains at least two chemicals that block replication of the bacterium Streptococcus mutans, a major cause of dental caries.

Qing-Yi Lu and Wenyuan Shi point out that more studies are needed before these compounds could ever be considered as additives for cavity-thwarting toothpaste or mouthwash. Chinese medicine has used licorice root for centuries and it is only recently that western science has been alerted to its potential in reducing inflammation, fighting viruses, and healing ulcers.

A word of caution though, too much licorice, whether in licorice candies, tea, or other foods, can trigger high blood pressure in susceptible people, far outweighing the protective effects on your teeth.

No Cellphone Cancer Link

It’s almost been as if the chattering classes were hoping to find that cellphones give you brain cancer. It would give them something else to chatter about, after all. But, the BBC reports that a study of almost 3000 people in the UK effectively debunks this myth – The amount of mobile phone use does not correlate with glioma, the most common form of brain tumour.

If you want to talk about this give me a call.

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Cat scat and schizophrenia

Imperial College is on a roll today, with the second press release appearing within seconds of the news reported in my earlier posting.

Now, IC scientists reckon they have found new evidence of link between cat faeces and schizophrenia. Sounds bizarre, but apparently invasion or replication of the parasite Toxoplasma gondii in rats can be inhibited by using the anti-psychotic or mood-stabilising drugs commonly prescribed for schizophrenia. T gondii is found in infected cat faeces and can be present in undercooked meat.

Joanne Webster and her colleagues reckon the activity of these drugs against the parasite suggests a role for it in causing mental problems in some patients.

At a time when the UK government is soon to back peddle on its lowering of the cannabis classification in law because of suspicions prolonged use can cause mental health problems, this finding could provide just the evidence the pro-pot lobby is after. Bird lovers too are provided with new evidence for an attack on their nemesis – the cat.

Vioxx Drugs Okay?

Researchers at Imperial College London and Queen Mary, London, are suggesting that drugs related to the withdrawn Vioxx may still be the best drugs for treating arthritis.

They argue that although Vioxx and related drugs have been associated with an increased risk of heart attack and stroke, the same might also be true for the more conventional non-steroid anti-inflammatory drugs (NSAIDs).

Jane Mitchell and her colleagues have reviewed the medical literature on the use of NSAIDs and Vioxx-like drugs and are convinced that despite the cardiovascular side-effects of certain COX-2 drugs they could still be the drug of choice for certain patients without cardiovascular risk factors, especially if they cannot tolerate NSAIDs because of the gastric side effects of those drugs.

It’s all about benefit-risk management (BRM) which sounds a little like marketing jargon, but underpins a much more effective attitude to medicine than holistically abandoning effective drugs.

Regardless of the status of Vioxx and its analogues there is much imminent movement in the pharmaceutical industry as the likes of GlaxoSmithkline vie for pole position in the market for the successor to COX-2 inhibitors. Of course, if Mitchell and her colleagues are right, then, the generic NSAID manufacturers could take another nice chunk of that market before it’s even opened up.

Flu is Not the Only Germ

Flu isn’t the only pathogenic threat at this time of year, according to a report on News Medical Net [link now defunct], metapneumovirus, rhinoviruses, coronaviruses, parainfluenza, respiratory syncytial virus (RSV), and others knock many of us for six each winter and are responsible for thousands of deaths. They don’t make the headlines because they’re not so easy to pronounce as “bird flu” nor is there anything particularly newsy about how you catch them (from doorknobs, faucets, and appliance handles, if you must know). They also lie dormant in your nose and lungs too waiting the right conditions to pounce. Despite their low profile, however, these are killer diseases that claim lives needlessly, while celebrity viruses such as H5N1 and SARS steal the headlines.

Turkish H5N1

This joint statement from the UK’s Medical Research Council’s National Institute for Medical Research and the World Health Organisation just in:

The genetic and antigenic analyses of viruses recovered from two fatal cases of H5N1 influenza in Turkey have been completed at the WHO International Influenza Centre at the MRC’s National Institute for Medical Research in Mill Hill, London.

These viruses are very closely related to current avian H5N1 viruses in Turkey, and also to those isolated at Qinghai Lake in Western China last year.

The gene sequences of the viruses indicate that they are sensitive to the antivirals Tamiflu and amantadine.

Virus from one of the human cases contains mutations in the receptor binding protein, haemagglutinin. One of these has been observed before in viruses from Hong Kong in 2003 and Vietnam in 2005. Research has indicated that the Hong Kong 2003 viruses preferred to bind to human cell receptors more than to avian receptors and it is expected that the Turkish virus will also have this characteristic.

You can read more on the bird flu story