Pricing Petrochemical Know-how

An informatics approach to pricing petrochemical products has been devised by scientists at the Market Research Department of the Research Institute of Petroleum Industry (RIPI) in Tehran, Iran. Their model puts a price on “know-how”, which is the most complicated activity of the commercialization stage.

Writing in the International Journal of Technology, Policy and Management, (2008, 8, 279-297), Reza Bandarian, Ahmad Mousaei, Abbasali Ghadirian and Maham Tabatabaei explain their approach. “The RIPI has a mission to bring ideas to market in terms of developing new technologies and new products,” they say, “Commercialization is one of the critical stages in this process.” Their model examines three pricing scenarios – optimistic, pessimistic and actual – for selling technology and was validate against historical data of various RIPI petrochemical products.

There are increasing demands on companies, not just in the petrochemicals sector but across the commercial spectrum. The marketplace needs better, faster and cheaper technology and products, while intellectual property, once simply seen as an expense has become an important source of revenue. Indeed, many of the problems seen in modern business hinge purely on IP rather than solid, hands-on extracted or manufactured resources. IP provides a critical competitive advantage for the firms that hold it but a serious disadvantage for those that do not.

Bandarian and colleagues point out that companies can no longer rely on the incremental innovation, i.e., improving on what has already been done, to compete and survive. Today it seems that “radical innovation” and “breakthrough products” are essential to long-term commercial sustenance. Even governments are beginning to recognize this in their wealth creation programs. The US National Science Foundation (NSF), which funds a huge amount of academic research in the USA not only demands that research projects are interesting, good quality and important scientifically, but that they also demonstrate the solution to a societal need or goal, which might be in constant flux.

The bottom line is that: “What customers want today, they will not want tomorrow, says the team. They point out that almost half the major corporations that existed in 1975 no longer trade. This is probably best explained by the fact that those corporations failing to grasp this simple tenet.

“One of the explanations for this dismal record is that companies are still trying to link emerging technologies with existing markets when they should be linking emerging technologies with emerging markets.”

In Iran and other countries of the Middle East, the researchers explain electronics, medicines and chemicals are major imports, while Iran’s national income comes essentially from oil production. Unfortunately, this resource has been used for wealth creation rather than technology creation. “Traditionally, the oil industry has improved in engineering maintenance while based on technology limitation; we have been kept behind that of developed countries, and the gap has increased.

This is perhaps the most important reason why Iran is the market leader in basic petrochemical products, but in high-value products, we have lost the market against developed countries,” the researchers add. They present a model that could allow innovation to seep, if not surge, through, by using know-how to evaluate and price innovative products, it is based on the low-cost and speed of current pricing models -experiential and mathematical – and side-steps their disadvantages of being untimely, requiring too much pre-market testing, and being highly skills dependent.

The researchers incorporate various factors into their model – the life cycle of know-how, annual market size, raw material and total production cost, selling price, net profit, earned income during investment, risk-free rate of return, know-how investment required, know-how return in its life cycle, know-how annual return in its life cycle, present value of know-how return in its life cycle.

Other factors can be fed into the model depending on the specific characteristics of the product in question. Indeed, “Our comprehensive framework of the commercialization of new technologies in the petroleum industry that can be used with some modification for other industries,” the researchers say. They tested their model retrospectively against RIPI product data and demonstrated an accuracy of around 97%.

Soft Option for Hard Water

Hard water

Well, after a week of sinning, today’s post is more straightforward science news. First up, a soft test for hard water. Researchers in Spain have developed an inexpensive, reusable, and portable hard water sensor based on a fluorescing strand of DNA that could preclude the need for time-consuming titration and or laboratory-bound atomic absorption spectroscopy methods and so be used in the field.

Also this week, aqueous nanovalves. Researchers in the US have developed a new type of molecular nanovalve that can control the flow of small molecules trapped within porous silica spheres. the device could be used as a novel drug-delivery agent as it operates in aqueous conditions and responds to changes in pH.

Finally, in my spectroscopynow column, I discussed the cloudiness of ouzo, pernod, pastis, and related beverages. Now, the mechanism of the cloud formation has been revealed but I am still curious as to why those who imbibe such aniseed-based drinks get a second hit the morning after the night before, when they have a drink water. Anyone who understands what that is all about should leave their thoughts in the comments below.

Drinking Softened Water

A Chemspy reader sent me an email asking about the best way to fix their water softener.

Hi, I have a water softener. I met a local repair service, not affiliated with the manufacturer in any way, who can rebuild my broken unit with better quality after-market parts. Sounds like a good plan to me.

So far so good…the reader goes on…

The repair guy proposes to add some good quality resin to the tank to “top it up” if needed, and to add charcoal to the resin tank as well, as a filter enhancement. He claims the charcoal will get cleaned when the resin goes through the water softener’s normal recharge.

Again, sounds reasonable to me, although I suspect that the efficiency of a unit will depend on the quality of the components and presumably the actual fault and how that has been repaired. But, it was the final sentence of the email that made my heart skip a beat.

I only know charcoal filters as something you put inline, and replace before it poisons the drinker with its collected contaminants. Could the charcoal really be recharged and have the same useful lifetime the resin has?

Can you spot the potentially fatal flaw in what this Chemspy reader is doing with his water softener? I can and I’ve emailed him to tell him to cease and desist with immediate effect or suffer the consequences…your thoughts in the comments below would be appreciated.

French Fries, Wild Mushrooms and Ouzo

Alchemist ChemWebA mixed bag this week in my Alchemist column on ChemWeb.com this week. First up, news that US$1 million is to be ploughed into biofuels research that could circumvent some of the serious environmental concerns associated with this renewable energy source.

In the world of pharmaceuticals we discover that there might be yet another string to the bow of aspirin-like drugs, this time in the fight against breast cancer. There’s good chemical news for those hoping to save Gulf Coast Wetlands from the rampages of the coypu with the discovery of a chemical lure, The Alchemist also hears of a novel system of surfactants and gelating agents that can form separate compartmentalized structures resembling the organelles in a living cell. You might care to have a drink with The Alchemist this week in celebration of a clearer understanding of why some drinks, such as ouzo, form cloudy emulsions with water. There’s more on the ouzo effect in my SpectroscopyNOW story on the subject where an independent team working in parallel have used NMR to take a look at these rare and peculiar emulsions.

Finally, a little kitchen chemistry could give your French fries a little je ne c’est quoi.

Edible wild mushrooms

Speaking of haute cuisine…also on this week’s SpectroscopyNOW, I report on how Portuguese scientists have identified a whole range of smelly molecules found in wild edible mushrooms. It’s pioneering work that will allow the food industry to ensure it is not being fobbed off with cheap mushrooms when a more expensive variety is what they ordered. The results could also be used by biotechnologists to engineer specific flavours into easily cultivatable varieties of mushroom. Two points arose as I was writing the item: The first is that overall mushrooms smell of nothing more complex than 1-octen-3-ol, which the researchers describe helpfully as having a mushroom-like odour. Secondly, the notion of cultivating wild things is at odds with the whole ethos of wild mushrooms, surely?

Either way, it’s hopefully an interesting read. Now, pass the ketchup for my mushrooms and fries, would ya?

Copyright and CAS Numbers

There’s discussion all over the chemical blogosphere at the moment about copyright and CAS numbers Chemspider’s Tony Williams first broached the subject in his blog and has followed up here. Cameron neylon has touched on the issue here as too have PeterMR and Kurt Wegner. If I’ve missed any links, please leave a reference to your post in the comments.

Anyway, here’s a thought…

Thumbnails (i.e. reduced size) versions of photos, images, and other visual creative works were recently the subject of a court case in the US, I believe. The judge suggested that displaying a thumbnail of an image was not a breach of copyright.

CAS registry numbers, InChIs, DOI’s and other such “creative works” might, in some sense, be considered an analog of an image thumbnail, and therefore may fall outside of a copyright claim similarly. Has anyone got the legal prowess to test such a case.

However, in writing this comment it occurred to me that there may be a more fundamental factor that would preclude CAS numbers being copyrighted. Aren’t they generated sequentially and automatically? If so, then perhaps they don’t fall under the description of “creative works” and therefore may not be copyrightable at all.

Girly Games

My latest science news write-ups on the SpectroscopyNOW portal are now up for grabs. This week, I cover the apparent gender gap when it comes to computer games, how Japanese researchers are using near-infrared light to probe young women’s brains to find out if they can reduce stress and potentially acne with pleasant fragrances, and the discovery that cancer cells seem to be stuffed full of the dreaded trans fats. You can find my other spec news from this week linked in the Sciencebase Geeky Bits column.

Perfect skinHowever, I want to step back a little with respect to that video games research. The team used the apparently powerful technique of functional MRI (basically a brain scan that can spot changes and lights up active regions of the brain). The researchers devised a very simple computer game, a kind of cross between Tetris and Pong (without the bats). To win you had to gain territory. The researchers scanned the brains of males and females while they played this game. Their results showed that men and women got the game, but the men were sharper when it came to realising you had to use a particular strategy to gain the most territory.

What was most interesting to Allan Reiss and colleagues at Stanford University School of Medicine who carried out the research was that the region of the brain associated with rewarding feelings lit up the most in the males than in the females. This, the researchers say, suggests a possible explanation as to why males enjoy, and even become addicted to, video games more commonly than females. “These gender differences may help explain why males are more attracted to, and more likely to become ‘hooked’ on video games than females,” Reiss explains in the Journal of Psychiatric Research.

Now, I take issue with the fundamental assumption that Reiss and his colleagues make regarding video games. While historically video games have been aimed almost squarely at boys, the manufacturers over the last few years have recognised that they only corner half the potential market with such a biased aim. As such, they have developed dozens of new types of games that are not of the familiar war and killing fantasy type. They have also remodelled their hardware to offer colours and skins that will appeal to females, the pink and white Nintendos, for instance, generally appeal to the female market more than the blue.

More to the point though, my ten-year old daughter and dozens, if not all, of her friends have taken to Nintendos, Wiis, Playstations, Tamagotchi, just as addictively as their male counterparts, fighting for screen time on their various devices and computers. Admittedly, the games they play are more frequently of the SingStar, Petz, and Sims kind as opposed to Halo, World of Warcraft etc. They also network with each other online in various online games with small furry animals rather than three-eyed aliens with vast armaments. Like I say, though, they are just as addicted to these games as the boys.

So, while Reiss’s work is fascinating and does hint vaguely at latent aspects of how territorialism evolved in the male brain. One has to wonder whether if he and his colleagues created a different type of game, a more “feminine” type game, like a pet simulation, for instance, they would see those reward centres lighting up more brightly in the female brain. Perhaps if the experiment had had an intrinsic bias towards a feminine type of game and they’d seen such activity in their fMRI, they would have come to a very different conclusion about video game addiction.

Chemical MSDS Sheets

Material safety data sheets (MSDS) is a perennial search favourite on the Chemspy site. The site has its own MSDS section and a javascript widget you can even add to your own site to allow your visitors to search for chemical MSDS sheets (yes, I know it’s a tautology on two counts, chemical material safety data sheets sheets, but like PIN number and “ATM machine”, the phrase is in common parlance.

Anyway, follow the link to search for MSDS on ChemSpy and here if you’d like to add the MSDS search toolbox (feel free to edit the script once you’ve saved it to your server to fit your site’s requirements).

Meanwhile, an offsite resource that looks promising for Chemical MSDS sheets is the obviously named MSDS Search, which duplicates some of the ChemSpy resources but adds a few new ones too.

YACJ – Nature Chemistry

April 2009 sees the launch of yet another chemistry journal, this one coming from Nature Publishing Group. It will, apparently, “provide a unique forum for the publication of high-quality research in all areas of chemistry.” Well, they would say that, they’re hardly going to tell us it’s a run-of-the-mill publication offering tedious and dead-end research, are they?

The launch site usefully reminds us that, “Chemistry is concerned with the study of matter on all levels, including its composition, structure, properties and how it can be transformed in chemical reactions.” Again, they’re not wrong there. But, speaking of definitions of chemistry, I thought Walt’s definition in Breaking Bad was pretty good.

If you don’t know about Breaking Bad (It’s not on UK TV yet, for instance), the plot involves a stressed-out, 50y old, high school chemistry teacher, who’s moonlighting at a carwash to make ends meet when he discovers his wife is pregnant and he’s dying of lung cancer. In desperation he hooks up with a crystal meth pusher and starts cooking up some highly pure and enormous crystals in the back of an RV. Needless to say the local dealers don’t like him muscling in on their patch, and he attempts to murder them (in the back of the RV) by pouring powdered red phosphorus on to a pan of boiling methanol. A quick lesson in the incredible corrosive properties of hydrofluoric acid – it burns through metal, rock, ceramic, but not polythene – all adds to the fun and games.

Anyway, Breaking Bad, with its periodic table credits, is a lot more entertaining than yet another chemistry journal. Although I am sure the Nature effort will turn out not to be YAFCJ at all but instead a major success, nudging JACS, Chem Comm, and Angewandte a little further along the virtual shelving.

Meanwhile, thanks for Chemistry Lab Notebook for the tip-off.

Full Spectrum Science News

Musical molecules

Musical molecules, bright fibres, polarised brain chemistry, and cholesterol regulation, all feature in my SpectroscopyNOW column this week.

Musical molecules – What do Schroedinger’s equation and Schoenberg’s expressionism have in common? Not a lot you might think. However, researchers in Germany and the US have now modelled the hydrogen molecule, the archetypal subject of molecular modelling, using a theory of behaviour that emerges from music. The study demonstrates how a hydrogen molecule responds to laser pulses as if the molecule’s vibrational motions, its quantum states, were the notes making up a changing musical chord and offers the opportunity of laser-controlled chemical reactions.

Fibre, fibre burning bright – A European research team has developed novel strategies for the rapid trace element analysis of metals in polyamide synthetic fibres by graphite furnace atomic absorption spectrometry and inductively coupled plasma mass spectrometry. Their method allows the accurate determination for quality control of polyamide products containing titanium dioxide as an optical brightener.

Bad cholesterol regulator – US researchers have discovered exactly how a destructive protein binds to and interferes with one of the molecules involved in removing low-density lipoproteins (LDL), the so-called “bad” cholesterol, from the blood.

Bipolar disorder – Spectroscopic studies of post mortem brain chemistry reveals that sufferers of bipolar disorder (often referred to as manic depression) have a distinct chemical signature linked to this mental illness. A collaboration between researchers in the UK and US also suggests a possible mode of action for the mood stabilisers used to treat the disorder and how they counteract changes in brain chemistry.

Drug Design on the Playstation

Serious drug design researchers are apparently hacking their PS3 machines to turn them into drug discovery workhorses. At least that’s according to my alma mater New Scientist magazine. It’s the kind of catchy subject they cover and is a classic from Mike Nagle.

The PS3 console uses a Cell chip, made by IBM, Sony and Toshiba, which is composed of a CPU and eight slave processors that run on Linux. According to NS, this chip is prized by chemists and physicists alike because the same kind of calculations it uses to produce the stunning, high-quality PS3 graphics for gaming are just about the same those needed to simulate reactions between particles, ranging from the molecular to the astronomical (apparently, you can do black holes with it too).

But, when we say they’re hacking the PS3, it’s not like these scientists are just plugging in a data cable and running their lab. According to NS, University of Massachusetts astrophysicist Gaurav Khanna has actually strung together 16 PS consoles to simulate the gravity waves that to occur when two black holes collide. While University of Illinois chemist Todd Martinez is running particle simulations on a Playstation, with 1000 atoms (a small protein in other words) that can be done 130 times faster than on an ordinary PC.

It’s all quite twee really, what with the surgeons cannibalizing their Wii consoles to do virtual operations and chemists latching on to the power of virtual world Second Life too. One can almost imagine the response of the peer review panels as the grant applications start to roll in with instrumentation inventories listing costs for 32 PS3 consoles, 20 Wii controllers, a couple of PSPs, and a dozen iPhones. The real test will come though if they can get away with tacking on a few copies of World of Warcraft and Nintendogs Labrador Retriever & Friends.