Heptastic science news

  • The full list: The Twitter 100 – Its 200 million users share 110 million messages a day – and if you don't know who rules the twittersphere, you don't understand the 21st-century world. This guide is a definitive who's who of the UK's tweet elite. Although for some reason they included me on the list (at #47, same as Armando Ianucci).
  • Why haven’t we cured cancer yet? – How many times have you been asked this question, how many times have you asked this question yourself? The answer boils down to the fact that cancer is not a single disease, it's hundreds of different diseases. Asking that question is like asking, "why haven't we cured viral infection?" or "why haven't we cured car accidents?". Even if we can cure one type effectively, there are hundreds of other types to deal with. Even the umbrella term "breast cancer" belies the fact that there are many different types of disease that lead to malignancy in breast tissue.
  • Recycling carbon – Technologies that can use carbon dioxide as a chemical feedstock are high on the agenda in the face of rising atmospheric levels of the greenhouse gas. A novel iron-based catalytic process studied using inductively coupled plasma (ICP) atomic emission spectrometry shows how carbon dioxide can be converted into the industrially useful formic acid at an 80% yield. Formic acid might also be used as a fuel cell fuel. The metal oxide by-product is readily reduced using glycerin derived from renewable sources releasing lactic acid, which could be used for biopolymer production.
  • Feverish research – There is neither vaccine nor cure for the Ebola and Marburg viruses, which cause fatal haemorrhagic fever in humans. However, a new NMR spectroscopic study by US researchers scientists has led to the discovery of a family of small molecules that apparently bind to the outer protein coat of the virus and halt its entry into human cells, so offering the possibility of an antiviral medication against the disease.
  • Structural biologists catch the pulse – Researchers have discovered that ultra-short X-ray pulses can produce exquisite measurements at the molecular level of biological objects by grabbing a "snapshot" just before the sample succumbs to radiation damage.
  • Enzymes against cocaine – The interaction of novel substrates for the enzyme butyrylcholinesterase (BChE) and mutants have been investigated using computational and correlation studies. The insights revealed could improve our understanding of how this enzyme, which metabolizes cocaine, might be modulated in drug therapy and the development of anti-addiction drugs.
  • Spectroscopy & Separation Science – We need the page to get 25 members so that we can switch to a nice short URL…please "like" the page.

From David Bradley Science Writer – seven science selections

An octet of science news

  • Perfect Perfume – a video for Valentine’s Day – A bit of fun for Valentine's Day as the team combinesto make our very own "perfect perfume"!
  • The lingering risk of thirdhand smoke – As Dubowski suggests, the notion of thirdhand smoke putatively being hazardous to health is controversial. Research in the late 2000s alluded to the potential problem of this form of pollution but ongoing public and academic scrutiny has not yet resolved the issue. Dubowski's work does provide a chemical basis for a possible risk but does not prove that the risk is substantial or otherwise. However, what is certain is that firsthand smoke is directly hazardous to the health of the smoker and recent evidence suggests that it could cause genetic damage almost the instant tobacco smoke is inhaled.
  • How marijuana works – Marijuana is the buds and leaves of the Cannabis sativa plant. This plant contains more than 400 chemicals, including delta-9-tetrahydrocannabinol (THC), the plant's main psychoactive chemical. THC is known to affect our brain's short-term memory. Additionally, marijuana affects motor coordination, increases your heart rate and raises levels of anxiety. Studies also show that marijuana contains cancer-causing chemicals typically associated with cigarettes. In this article, you will learn about marijuana, why this drug is so popular and what effects it has on your mind and body.
  • Tweeting the lab – The question of how to build an efficient and useable laboratory recording system is fundamentally one of how much information is necessary to record and how much of that can be recorded while bothering the researcher themselves as little as possible.
  • Kepler discovers a mini solar system – Using NASA’s orbiting Kepler observatory, astronomers have found a complete solar system of six planets orbiting a sun-like star… and it’s really weird: five of the six planets huddle closer to their star than Mercury does to the Sun!
  • Triclosan – should be used medically and banned in personal products – Triclosan is a really useful material with antibacterial and antiinflammatory properties but it should be banned from use in personal care ingredients.
  • Sciencebase Presents… – Nerdy, geeky, dorky science videos. Classic stuff, will be loved by nerds, geeks and dorks everywhere!
  • JournalTOCs – 15,204 journals (including 1,676 Open Access journals) collected from 706 publishers. Very easy to browse and to create custom feeds for specific subject areas e.g. http://www.journaltocs.hw.ac.uk/api/articles/chemistry Just swap out "chemistry" for your chosen subject.

From David Bradley Science Writer – Eight science picks

Free chemistry dictionary

TL:DR – Sciencebase has hosted an excellent chemistry dictionary for many years. You can download it here and use it with your word processor in spellchecking.


UPDATE: Version 3.0 of the chemistry dictionary is now available. Now, with crowd-sourced, user-submitted words and an OpenOffice.org dictionary extension.

“It took me the better part of a month,” Azman told us, “but I’ve made my own and I want it to be as open-source as possible. Sciencebase is now hosting Azman’s efforts ready for free download zipped chemical dictionary file here). The chemistry dictionary is in standard “.dic” format and instructions for installing it on Microsoft Word OpenOffice can be found in the download together with licensing information (it’s creative commons).

Chemistry Dictionary

Azman concedes that it is not yet perfect and focuses mainly on organic chemistry words. “It almost certainly contains at least one error and misspelled word that sneaked through,” he confesses, “I tried to get as many of the conjugations as possible (-e, -es, -ed, -ing, -tion, etc), but probably missed several.” He also points out that it employs only US spellings.

“I don’t know how helpful it will be to an average chemist,” Azman told me, “but organic chemists should love it. From the organic perspective, I did not systematically go through and list every iterative derivative of every compound (methylbenzene, ethylbenzene, dimethylbenzene, fluorobenzene, etc.),” he adds, which could be something of a limitation compared to the paid for program which has 1,800,000 words compared to the 8000 or so entries in Azman’s dictionary. However, he did vet his list using the current ASAPs of JACS, JOC, and OL to catch some of the iterations he missed initially. “There are a surprising number of typos in those articles,” he points out.

Personally, I’ve had a medical dictionary running in my word processor for years, but this organic dictionary will complement that nicely and save me a lot of repeated add to dictionary clicks when writing around the subject of organic chemistry.

Azman is currently working on automating the iteration process with an Excel expert and as soon as that task is complete we’ll let you know so you can download the .dic file and install into your word processor.

Free Download: Chemistry Dictionary for Word/OpenOffice

Keywords: Open Access Chemistry Dictionary, Open Source Chemistry Dictionary, Microsoft Word Chemistry Dictionary, OpenOffice Chemical Dictionary.

This item originally appeared on my Chemspy site back in the 2000s and was first released on Sciencebase 2008-02-08 at 13h00 GMT.

Even more science news

Science news snippets from the net meanderings of David Bradley

  • Sir David King on climate change – King said, “We hear enough from the climate change skeptics that I have to repeat some fundamentals that you’ve probably heard before.” Fifty-five million years ago, atmospheric CO2 concentrations stood at about 1,000 ppm and global temperatures were much higher and ocean levels were about 110 m higher than they are today. Large mammals developed on Antarctica because the climatic conditions on all of the other continents were inhospitable to such development.<br />
    <br />
    In the past 500,000 years, every ice age was characterized by atmospheric CO2 concentrations around 200 ppm; every short interglacial period by concentrations around 285 ppm, which was also the preindustrial atmospheric concentration of CO2. Today, the atmospheric CO2 concentration stands at 389 ppm and is rising by 2 ppm per year.<br />
    <br />
    “Could we get back to 1,000 ppm CO2 by burning all of the fossil fuel on Earth?” King asked. “Yes.”
  • Save the Forensic Science Service – Brits are starting to get a feel for what it must have been like for US scientists under Dubya with the hacking and slashing of science that the current unelected UK government is doing. Petitions might help…
  • Switching to a standing desk – Is it time we desk jockeys made the switch to a standing desk? I wouldn't be too quick to rush into this form of working. Yes, it's not a good idea to spend 50 hours a week hunched over a desk, but your feet and the vascular system in your legs will not thank you in years to come for standing for that length of time each week. Maybe it's choice between avoiding a lardy arse now and varicose veins later…
  • Microsoft Mathematics 4.0 – Microsoft Mathematics provides a graphing calculator that plots in 2D and 3D, step-by-step equation solving, and useful tools to help students with math and science studies.
  • ScienceSeeker – ScienceSeeker collects posts from hundreds of science blogs around the world, so you can find the latest science news and discussion on any topic.
  • Biotechnology & Pharmaceuticals Magazines, White Papers, Reports, and eBooks – Launched today, the Chemspy chemical and pharma resources site. Those in the industry or academia qualify for free biotechnology & pharma magazines, so-called white papers, eBooks and reports.

Science news

Science news snippets

  • Herpes target – UK scientists have used solution-state NMR spectroscopy for the first time to develop a 3D picture of a herpes virus protein interacting with a key part of the human cellular machinery. The study improves our understanding of how the virus hijacks human cells and could eventually lead to new targets for drug therapy.
  • Bacterial sense – A new biosensor platform for the detection of bacterial pathogens, specifically demonstrated with E coli, has been developed based on long-range surface plasmon-enhanced fluorescence spectroscopy (LRSP-FS). Chun-Jen Huang, Jakub Dostalek, Angela Sessitsch and Wolfgang Knoll of the Health and Environment Department, at the Austrian Institute of Technology GmbH, in Vienna, explain how increasing awareness of food safety and the risks associated with various microbial pathogens carried in food and drinking water, in particular Escherichia coli O157:H7, mean identifying when such pathogens are present is becoming more and more important.
  • 7 of the biggest tobacco myths – When it comes to Big Tobacco, what we have are lies, lies, and still more lies. The myths about tobacco abound in all shapes and sizes. But being aware of these untruths can make you a better and healthier (non)consumer. More importantly, being knowledgeable about these myths can even save you life. Here are seven myths coupled with the cold, hard truth about tobacco use.
  • ChemSpy.com makes the most important chemistry search and chemical databases available – Redesigning (with graphene theme) my old ChemSpy site, adding new content, updating legacy pages, modernising, overhauling, rebuilding, reconstructing…you get the picture. Chemistry news and search.
  • 2011 conferences – Wendy Warr publishes her annual listing of conferences and meetings relevant to chemists and chemical librarians.
  • Free guide to science communication – Free ebook download of Frank Burnet’s ‘Why and how to communicate your research’

This week’s science news snippets

  • International Year of Chemistry, "Naturally" – Nature's take on the launch of the International Year of Chemistry 2011 (IYC11)
  • Stinging vision – A group of school children aged between 8 and 10 years old have had their school science project accepted for publication in an internationally recognised peer-reviewed journal. The paper, which reports novel findings in how bumblebees perceive colour, is published in the Royal Society journal Biology Letters.
  • Physical Methods – Organophoshorus Chemistry provides a comprehensive and critical review of the recent literature. Coverage includes phosphines and their chalcogenides, phosphonium salts, low coordination number phosphorus compounds, penta- and hexa- coordinated compounds, tervalent phosphorus acid derivatives, quiquevalent phosphorus acids, nucleotides and nucleic aicds, ylides and related compounds, phosphazenes and the application of physical methods in the study of organophosphorus compounds. This Specialist Periodical Report will be of value to research workers in universities, government and industrial research organisations whose work involves the use of organophosphorus compounds. It provides a concise but comprehensive survey of a vast field of study, with a wide variety of applications, enabling the reader to keep abreast of the latest developments in their specialist fields.
  • Homeopathy on the ropes – Homeopaths who recommend remedies for the prevention of serious infectious diseases are now coming under the spotlight, while vets no longer have homeopathic treatments as an option unless someone can prove they work. Homeopathy 1796-2011 RIP
  • Swine flu symptoms – If you or a member of your family has a fever or high temperature (over 38C/100.4F) and two or more of the following symptoms, you may have H1N1 flu: unusual tiredness, headache, runny nose, sore throat, shortness of breath or cough, loss of appetite, aching muscles, diarrhoea or vomiting. It should be emphasised that you could still have swine flu with any combination of these or even an almost complete lack of symptoms, but if you're in a vulnerable group (pregnant, asthmatic, lung disease etc) get checked out if these are manifest.

Science news with a spectral twist

Science news with a spectral twist, first 2011 issue of my spectroscopyNOW.com now live

  • Fast-track walking pneumonia test – A new approach to testing for a common form of pneumonia using nanorod arrays to boost SERS signals can cut the time to diagnosis from several days to a mere ten minutes, according to research published in the journal Plos One.
  • Conservation conversation – Improving storage and exposure conditions in conservation of artefacts is crucial to suppressing the fading and degradation of dyes and other components of paintings. Researchers have now used several analytical techniques, including attenuated total reflectance infrared spectroscopy, Raman spectroscopy, reflectance UV-Vis spectroscopy, X-ray fluorescence spectroscopy and optical microscopy, to investigate different conditions on common pigments
  • MRI by contrast – Magnetic resonance imaging contrast agents are currently designed by modifying their structural and physiochemical properties to improve relaxivity and to enhance image contrast. A new approach based on porous, disk-shaped "nests" for nanotubes could offer a way to improve contrast by increasing relaxivity through the confinement of the contrast agent within nanoporous silicon.
  • Diversity beyond compare – The crystal structure of taxadiene synthase, an enzyme key to terpene biosynthesis in many living organisms, confirms a theoretically predicted link between two enzyme classes in the evolution of compounds such as the natural product anticancer drug Taxol.
  • Metabolic insights into celiac disease – Celiac disease (CD) is an autoimmune disorder caused by a permanent sensitivity to gluten in genetically susceptible individuals. A nuclear magnetic resonance spectroscopic approach to the disease could allow accurate and early diagnosis using metabonomics.
  • Well-stacked molecules – Japanese scientist Hiromitsu Maeda of Risumeikan University and his colleagues have turned to the well-known molecular motif of the pyrrole to make a new class of structured materials. By combining planar pyrrole-containing negatively charged complexes with similarly planar, positively charged organic ions they can generate fibres and soft materials, such as supramolecular gels and liquid crystals based on these organic salts.
  • Scientists use Wiimote to measure water evaporation rates – recently published report in the Water Resources Research academic journal describes an experiment undertaken by a team tasked with measuring evaporation rates by monitoring water levels. Rather than use a hypersensitive monitor or a high tech ballast system, they used a Wiimote.

Six science books for the holiday season

Six science books for the holiday season subjects as diverse as molecular biology pioneer Sydney Brenner, the question of antimatter, how scientists can better explain their research to non-scientists, a history of the chemical elements, scientific feuds and how innovators exploit business and technology trends.

  • Minitrends – Minitrends are emerging trends that promise to become significantly important within 2-5 years, but are not generally recognized. Unlike megatrends or microtrends, Minitrends are of a scope and importance to offer attractive opportunities to individuals and businesses of all sizes. The one that caught my eye is mention of nanotechnology and how it could be used in water purification and to make "fake" bone (I think they mean "artificial")!
  • Scientific Feuds – Most science histories present a triumphant march through time, with revolutionary thinkers and their discoveries following in orderly progression. The truth, however, is very different. In Scientific Feuds, Joel Levy offers a collection of the most vicious battles among the greatest minds. It features such contests as Huxley and Wilberforce's debate on Darwin's theory of evolution, Franklin and Wilkins' fight over the discovery of DNA, and the “War of Currents” between Tesla and Edison (which ended with Edison electrocuting dogs and horses in a vain attempt to discredit Tesla's work). From passionate competition to vindictive sniping, these rivalries prove that the world of science is just as political and emotive as the rest of human endeavour.
  • The Disappearing Spoon – The fascinating tales in The Disappearing Spoon follow carbon, neon, silicon, gold and every single element on the table as they play out their parts in human history, finance, mythology, conflict, the arts, medicine and the lives of the (frequently) mad scientists who discovered them.
  • Explaining Research – A comprehensive guide for scientists, engineers, and physicians that draws on Dennis Meredith's forty-year career in research communications. It shows how scientists can disseminate their discoveries to important audiences and explains how to use websites, blogs, videos, webinars, old-fashioned lectures, news releases, and lay-level articles to reach key audiences, emphasizing along the way that a strong understanding of the audience in question will allow a more effective communication..
  • Sydney Brenner: A Biography – Nobel Laureate Sydney Brenner has made some of the most significant discoveries in molecular biology. His reach extends way beyond his own research and has inspired countless young scientists and promoted the development of science and biotechnology around the world. Friedberg's book is based on Brenner's recollections as well as contributions and correspondence from his close friends and colleagues. It tells the lively story, not only of Brenner himself, but of what came to be known as the golden age of biology.
  • The 4 Percent Universe – Only 4 percent of the universe consists of the matter that makes up you, me, our books, and every star and planet. Over the past few decades, a handful of scientists have been racing to explain what the other 96% of "everything" actually is. In The 4 Percent Universe: Dark Matter, Dark Energy, and the Race to Discover the Rest of Reality, writer Richard Panek tells the story of the search for dark matter and dark energy based on in-depth reporting and interviews with the major players—from Berkeley’s feisty, excitable Saul Perlmutter and Harvard’s witty but exacting Robert Kirshner to the doyenne of astronomy, Vera Rubin.
  • Okay, I said six, but actually there’s a bonus book, the cover of which is shown above: The Ultimate Quotable Einstein, which just landed on my desk this week and is packed with the unmistakable wit and wisdom of one of the greatest thinkers of the twentieth, and perhaps any century.

More thoughts on science from sciencebase

My latest science news updates

  • Low-allergy wine, true blood, boronic butterflies – The Alchemist learns of low-allergy wines could one day be possible thanks to the discovery of glycoproteins in the tipple that seem to trigger the sniffles and headaches in susceptible drinkers. In analytical news true blood is spotted using infrared and one of the most complex small molecules is approved for treating metastatic breast cancer. In the world of agriculture a new discovery could point the way to boosting a crop plant's defenses against pests without pesticides and a butterfly effect is observed in boron compounds that could lead chemists to the elusive boron-boron triple bond. Finally, more than forty years of dedication to polymerization earns Marino Xanthos a major award.
  • Not another planet! – Less than 20 years after confirming the first planet beyond our own solar system, astronomers have bagged exoplanet No. 500. The milestone was reported by Extrasolar Planets Encyclopedia, a database compiled by astrobiologist Jean Schneider of the Paris-Meudon Observatory.
  • Enigmatic papers could stay in the UK – Papers published by World War II codebreaker Alan Turing have failed to sell at auction – raising hopes they could be kept in the UK.

Pharma industry could thrive in open

The pharmaceutical industry is facing tough times. The patents for many of the billion-dollar blockbuster drugs have expired, generics have taken market share. Health insurance companies and national health services are under increasing pressure to cut costs. Manufacturers and governments in the developing world are either ignoring intellectual property rights totally and producing generics for their poor sick.

Moreover, the pipeline is almost empty. Many old diseases the yielded blockbuster drugs have become resistant or are proving too difficult to tackle with traditional small molecule science. The decade-old promise of the Human Genome Project in the form of pharmacogenomics is not yet living up to its full potential, while the diseases of old age represent a new pipeline but the complexity of these illnesses – Alzheimer’s, Parkinson’s, cancer, cardiovascular, even obesity and aging itself – seem to require something more than pharmaceutical intervention. However, macromolecular medicine using peptides, proteins, and genetically modified antibodies are struggling to get out of clinical trials and into the clinic.

The pharma industry also faces increasing pressure from regulators, activists, and patient advocacy groups (not necessarily a bad thing in some ways). The main problem remains, of course, that these days research and development costs billions and takes many years to bring a new drug to market that might not give the company a decent payback on its investment within the patent lifespan.

Ram Subramanian and C. Jayachandran of Montclair State University, in New Jersey, USA, and Jeffrey Toney of Kean University, NJ, suggest that it is time for the pharma industry to reinvent itself, or at least adapt to adopt the ethic of open innovation. They’re not the only ones, of course.

Until now the industry has attempted to rebuild its fortresses through multibillion dollar acquisitions, which suggest that it feels money is yet to be made from medicine. But such consolidation does not pump new products into the drug discovery pipeline it simply funnels the near-empty R&D conduits into a shrinking number of product vats. In 2007, the US Food & Drug Administration approved just 17 new drug products for market, the lowest number since 1983.

The way forward might lie in open innovation where a company initiates a project in cooperation with others outside its boundaries and so accelerates the R&D process as well as cutting costs. This approach has worked successfully outside the pharma industry and some companies, Merck partnering with India’s Piramal Life Sciences and Eli Lilly with Jubilant Biosys are already beginning to see the possibilities.

“As innovation models have evolved, the sixth generation model calls for opening up the innovation process to provide a seamless interface between the focal organisation and a network of, among others, competitors, suppliers, and firms from other industries,” the team says. Of course, given the long lead times to market and the intrinsically scientific nature of the drug discovery process, new models that have worked for technology companies such as IBM and for consumer product manufacturers like P&G may not be entirely appropriate for the pharmaceutical industry.

Research Blogging IconRam Subramanian, Jeffrey H. Toney, & C. Jayachandran (2011). The evolution of research and development in the pharmaceutical industry: toward the open innovation model — can pharma reinvent itself? Int. J. Business Innovation and Research, 5 (1), 63-74