Red Red Wine

red red wine

An ideal solution for accurately and rapidly monitoring red, red wine during the fermentation process without the need for direct sampling for chemical analysis has been developed by Australian researchers led by Daniel Cozzolino of the Australian Wine Research Institute, in Adelaide.
The team recognised the need of the modern wine industry for tools that can assist in process control and quality assessment during fermentation and bottling but that can be carried out without complex sampling, preparation by an external lab. they have used chemometrics and Visible-near infrared spectroscopy to monitor concentrations of sugars and phenolic compounds, in red wine and so offer the industry a new approach to quality control.

Uncork vintage news here.

Dietary stress

fat rat

“Diet is an important part of healthy living,” Jeremy Nicholson of Imperial College revealed to SpectroscopyNOW, “it is just some things that are supposed to relieve stress – and widely touted by healthfood companies as being good for you – do not metabolically ameliorate the effects of even very minor experimental stress.” He and his colleagues have used NMR spectroscopy to analyse marker compounds in blood samples from rats under stress that have had their food switched to included polyunsaturated fats. “No one has actually tested this particular health claim before and this one doesnt stand up well,” Nicholson says. Additionally, the research shows it is possible to accurately measure and quantify how changing diet impacts health. This could ultimately lead to the development of more targeted and more effective products.

You can read the full details in my news round-up on spectroscopynow.com

Chronic fatigue diagnosis

The cause of CFS, also known as myalgic encephalomyelitis (ME), post-viral fatigue syndrome (PVFS), is not yet known and its symptoms are broad, ranging from fatigue, pain, muscle weakness, and depression to digestive disturbances, immune system weakness, and breathing problems. Moreover, there is no simple diagnostic test for the disease and patients often rely on a sympathetic physician to recognise the problem, but who, nevertheless, does not necessarily have the tools to offer a definitive answer nor an effective treatment. An objective clinical diagnostic test would make understanding and treating this disease far easier. Japanes researchers have now used a type of infra-red spectroscopy to distinguish between plasma from CFS patients and healthy volunteers. They reckon a non-invasive test will be available soon.

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Smartening Raman

Raman spectroscopy can provide elegant views of even the most mixed of materials at the sub-microscopic scale, even picking out chemical bonds. And, because it is sensitive to the lightweight elements found in covalent bonds it can provide detailed information that is inaccessible to sophisticated X-ray techniques. However, Raman is yet to be widely adopted because it suffers from potentially debilitating resolution issues and takes too long for all but the most patient of laboratories.

Now. French researchers have found a way to create a map of the incident laser beam used in Raman spectroscopy which brings it up to speed and could make it a more accessible technique.

More in the latest issue of SpectroscopyNOW.com

Scientific Rock Band

Regular readers may have noticed I’m in a list-making mood these last few days, with the NMR acronyms feature and “what scientists are known for” posts…well over on The Island of Doubt, fellow science writer James Hrynyshyn is discussing the issue of the scientific ethic in rock and mentions the likes of Talking Heads, Rush, and Thomas Dolby as being hot on science.

Well, it got me thinking about actual artist names that betray a hint of the technophile or the science-minded among the muso crowd, so here’s a short list…in no particular order:

Chemical Brothers (chem)
We are Scientists (gen)
Cure (med)
EMF (tech)
X-ray Spex (tech)
AC/DC (tech)
Spock’s Beard (sci-fi)
Bio-Com (bio)
Medicine Head (med)
Television (tech)
10cc (bio)
UFO (sci-fi)
TLC (chem)
Atomic Kitten (phys/bio)
Atomic Rooster (phys/bio)
Transister (tech)
Quantum Jump (phys)
William Orbit (astro)
Oxide and Neutrino (chem/phys)
Suzanne Vega (astro)
Quake (geo)
Tenth Planet (astro)
Mercury Rev (chem/astro)
Electronic (tech)
Quartz (geo)
Electric Light Orchestra (tech)
Neil Diamond (geo)
Multi Purpose Chemical (chem)
The Dead Science (formerly The Sweet Science) (gen)
Electric Soft Parade (tech)
Death Comet Crew (astro)
Nuclear Rabbit (phys)
Electric Prunes (tech)
The Mars Volta (astro)
Radiohead (tech)
Van Der Graaf Generator (tech)
My Chemical Romance (chem)
Chemical People (chem)
Electric Six (tech)
Mind Science of the Mind (gen)
Flux Information Sciences (info)
Skin (derma)
Scientist (gen)
Eat Static (tech)
Echo and the Bunnymen (audio)

Noesy Spectroscopists

Who says chemists don’t have a sense of humour, if you haven’t already seen Paul May’s Silly Molecules site check that out right now, but in the meantime some genuine acronyms from the world of spectroscopy

Insensitive Nuclei Enhanced by Polarization Transfer (INEPT)

Combined Rotation And Multiple Pulse Spectroscopy (CRAMPS)

HOmonucleaR ROtary Resonance (HORROR)

Nuclear Overhauser Effect SpectroscopY (NOESY)

COrrelation SpectroscopY (COSY)

Slice Interleaved Depth Resolved Surface Coil Spectroscopy (SLITDRESS)

Proton Enhanced Nuclear Induction Spectroscopy (P…you got it), which is often hyphenated with the next technique in the style of separations scientists who couple HPLC with ESI/MS and LC with DAD. Do I have to spell it out? We’d have P-V or V-P for that matter, depending on which technique came first.

Variably Adjusted Gamma Inhibiting Nuclear Association Spectroscopy (Okay, I made that one up, but I’m sure a spectroscopists somewhere is working on something similar), Hyphenated 2D versions of either this or the previous proton technique would be P-P and V-V.

There are many others including, CYCLOPS, HOHAHA, ROESY, SECSY, PASADENA, EXORCYCLE, DANTE, TOSS, INADEQUATE, ENDOR, FOCSY, HERPECS, DEPT, feel free to use the acronym search tool to validate the more suspect ones if you don’t trust me. Enter the acronym or abbreviation of interest in the yellow box on the right of that page and hit the GO button next to the phrase “Science Acronyms”.

Lead in China’s children

Researchers in Beijing have carried out a meta-analysis of AAS and ICP-MS results published during 1994-2004 to obtain a countrywide picture of how the level of lead in children’s blood is changing and how where they live effects their exposure to this toxic element.

Perhaps predictably, the team found that those children living in urban or industrial regions had much higher levels of lead than those living in rural areas. The figures they reviewed also contrast sharply with the children’s western counterparts who have much lower lead levels on average. The issue is a matter of significant public health importance for China, the researchers say.

Exposure to lead can affect the central nervous system and affect learning ability and growth. It is ubiquitous in the environment and can be absorbed in the human body by inhalation and ingestion from a variety of sources such as contaminated water, soil, food, lead-containing products such as paint and from vehicle exhausts in areas where tetra-ethyl lead is still used as engine an anti-knocking agent.

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Anaerobics class

A QSPR (quantitative structure-property relationship) study of the anaerobic biodegradation of chlorophenols could lead to an improvement in the disposal of these potentially carcinogenic industrial waste products.

Youzhi Dai, Dasen Yang, Fei Zhu, Lanyan Wu, Xiangzheng Yang, and Jianhua Li of the Department of Environmental Engineering, at Xiangtan University, People’s Republic of China have based their analysis on quantum chemical and physicochemical descriptors, using partial least squares analysis to obtain a good prediction of the QSPR for the disappearance rate constant (logK) of chlorophenols (CPs) in an anaerobic microbial culture.

More…

A peak you reach

Rather than relying on MRI and follow-up biopsy to provide information about a suspect abnormality in the breast, researchers at the Memorial Sloan-Kettering Cancer Center in New York have demonstrated in preliminary trials that NMR spectroscopy could be used to significantly reduce the number of biopsies required to detect the early stages of breast cancer. NMR can lock on to the choline peak associated with malignancy during the MRI scan.

MR spectroscopy cancer

Lia Bartella MD and her colleagues found that NMR could reduce the need for biopsy by 58%. They demonstrated that 23 of 40 suspicious lesions could have been spared biopsy, and none of the resultant cancers would have been missed, in a study group. “All cancers in this study were identified with MR spectroscopy,” explains Bartella, “There were no false-negative results. These results should encourage more women to take this potentially life-saving test.”

More…

Totally tubular peptide rings

peptide nanotubes

The highly unique crystal structure of nanotubes constructed from cyclic peptides is revealed this month by Japanese researchers in the journal Organic Biomolecular Chemistry. The descendents of these novel nanotubes could find a role in future molecular electronic devices, according to the team, who allude to the high macrodipole moment of their materials.

Shunsaku Kimura and colleagues at Kyoto University, have built on the work of ETH’s Dieter Seebach and Wisconsin’s Sam Gellman to use supramolecular chemistry to construct through self-assembly a stacked column of cyclic peptides, themselves made from three ACHC amino acids linked in a ring. ACHC is the trans-2-aminocyclohexylcarboxylic acid. The team used Fourier transform infra-red and nuclear magnetic resonance spectroscopy measurements and computational calculations to demonstrate that this cyclic tri-beta-peptide has C3-symmetry with the amide groups in the trans positions.

To read my full article visit the spectroscopyNOW.com crystallography channel.