TL:DR – Anecdote is not evidence, but I feel like I gained some benefit from taking a multivitamin supplement, it probably compensated for poor absorption of iron and perhaps other vitamins caused by one of my prescription medicines.
I’ve always been wary of taking vitamins and other supplements. There are good reasons not to do so, if you have a reasonably balanced diet. Excesses of some vitamins and minerals can lead to problems like kidney and liver damage, kidney stones, and some can interfere with the absorption and activity of prescription medicines.
However.
I have been feeling rather tired in recent months, becoming unaccustomedly exhausted after even light activity. I’m talking after a short walk, but sometimes even just after a shower. Was it long-COVID, was it my medication, was it just me getting older?
Mrs Sciencebase had an iron and vitamin supplement for an unrelated reason and suggested I try it, see if it would help.
Well, I took the recommended dose for a few days, not expecting to experience much improvement. Amazingly though, I felt a remarkable change in what people commonly refer to as “energy levels”. Activities that had started to become a tiring chore became a lot easier, I hopped on my bike and did a decent half an hour’s cycling without breaking a sweat, a couple of days after that I did an hour, at speed, and aside from being thirsty when I got back to base, I was fine.
I know anecdote is not evidence, but honestly, it seems like too much of a coincidence that I felt like I had recovered from apparent chronic exhaustion within three days or so of taking the supplement. Moreover, when I look at the side effects of one of my medications, it does suggest that tiredness and various other side effects are associated with reduced absorption of micronutrients (vitamins and minerals). So, I’m sticking with the supplement for a while longer.
Intriguingly, the effects do not seem to have been wholly physical though. Most people have had a tough few years, but there has been significant family loss and stress here that happened in the middle of covid, is ongoing, and I have not been what you might call the happiest bunny in the warren, for a long tim, I must confess. Stuff that I usually really enjoy has not, on too many occasions, brought me much joy in recent months. I shrugged it off as being the grief and worry…but…a few days ago, I felt like the proverbial cloud had lifted, and even though it was a drizzly day, the sun seemed to be shining again.
Could this too have been a supplement fix? Well, there are many, many biochemical pathways that are linked to mental health, disturbance in some of those are known to be connected to depression. These various pathways need various micronutrients to work properly. Might I have been deficient in an essential biochemical component? Have I now replenished my supplies and rebooted those pathwats?
Perhaps the brain, when faced with deficiency, goes into some kind of lockdown to make you mope, reduce motivation, and so activity? And, when that lockdown is prolonged and deep, could it also begin to impinge on other pathways to the detriment of mental health. If so, I wonder if this is exacerbated in the wake of a double-dose of grief accompanied by a lot of not unwarranted stresses and anxieties.
I don’t know. Like I say, anecdote is not evidence. I’d rather not take the supplements for a prolonged period of time, so I will be having a chat with my doc at my annual review about my current medication. I will tell them that what I do know is that I’ve been taking a daily dose of micronutrients and feel physically much fitter than I have for a long time and mentally far brighter.
As a footnote, I shared this post on my Mastodon and a couple of people suggested that my experience may be due to my “taking control” or simply a placebo effect. Well, that is a possibility, of course. However, I’ve had symptoms for a long time that coincide with several mentioned on the documentation accompanying one of my medications and I feel that reversion to the mean/norm (basically, the placebo effect) was so sudden and coincided with taking the supplement that there must have been a physical effect of doing so rather than my spontaneously recovering…but, again, anecdote is not evidence, either way. One cannot do double-blind, placebo-controlled studies on oneself.